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    Grb7 growth factor receptor bound protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84427, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Grb7provided by RGD
    Official Full Name
    growth factor receptor bound protein 7provided by RGD
    Primary source
    RGD:619759
    See related
    EnsemblRapid:ENSRNOG00000006990 AllianceGenome:RGD:619759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of translation; positive regulation of cell migration; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and focal adhesion. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 40.4), Liver (RPKM 28.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grb7 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83936538..83949344)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83443387..83453057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86393186..86408893)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene migration and invasion enhancer 1 Neighboring gene IKAROS family zinc finger 3 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study. Stroes CI, et al. J Clin Oncol, 2020 Feb 10. PMID 31809243, Free PMC Article
    2. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. Tanaka S, et al. J Cell Physiol, 2000 Jun. PMID 10797316
    3. Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas. Maqani N, et al. Mol Cancer Res, 2006 Jul. PMID 16849520
    4. Grb7-SH2 domain dimerisation is affected by a single point mutation. Porter CJ, et al. Eur Biophys J, 2005 Jul. PMID 15841400
    5. Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. Tanaka S, et al. Cancer Res, 1997 Jan 1. PMID 8988034

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EGF also activates focal adhesion kinase in the cytoplasm to rephosphorylate Grb7, releasing KOR mRNA for active translation.
      Title: Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93307

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 7
    Names
    GRB7 adapter protein
    epidermal growth factor receptor GRB-7
    growth factor receptor binding protein GRB7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053403.2 → NP_445855.1  growth factor receptor-bound protein 7

      See identical proteins and their annotated locations for NP_445855.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081757
      UniProtKB/Swiss-Prot
      Q9QZC5
      UniProtKB/TrEMBL
      A0A8I6AA75
      Related
      ENSRNOP00000009299.5, ENSRNOT00000009299.8
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83936538..83949344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269991.1 → XP_063126061.1  growth factor receptor-bound protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZC5

    2. XM_039086969.2 → XP_038942897.1  growth factor receptor-bound protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZC5
      UniProtKB/TrEMBL
      A0A8I6AA75
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)

    3. XM_006247433.5 → XP_006247495.1  growth factor receptor-bound protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006247495.1

      UniProtKB/Swiss-Prot
      Q9QZC5
      UniProtKB/TrEMBL
      A0A8I6AA75
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZC5.1 GenPept UniProtKB/Swiss-Prot:Q9QZC5

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