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    Psmd3 proteasome 26S subunit, non-ATPase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmd3provided by RGD
    Official Full Name
    proteasome 26S subunit, non-ATPase 3provided by RGD
    Primary source
    RGD:1311470
    See related
    EnsemblRapid:ENSRNOG00000028103 AllianceGenome:RGD:1311470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 186.5), Kidney (RPKM 183.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmd3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84139249..84151879)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83643473..83655620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86599007..86611180)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3C Neighboring gene gasdermin A Neighboring gene colony stimulating factor 3 Neighboring gene mediator complex subunit 24 Neighboring gene small nucleolar RNA, C/D box 124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
    2. Phosphorylation of ATPase subunits of the 26S proteasome. Mason GG, et al. FEBS Lett, 1998 Jul 3. PMID 9688553
    3. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
    4. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
    5. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94658

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 3
    Names
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
    proteasome 26S non-ATPase subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008281.1 → NP_001008282.1  26S proteasome non-ATPase regulatory subunit 3

      See identical proteins and their annotated locations for NP_001008282.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085881
      UniProtKB/TrEMBL
      A6HIT6, F7EYU0, Q5U2S7
      Related
      ENSRNOP00000037928.3, ENSRNOT00000039836.6
      Conserved Domains (2) summary
      pfam01399
      Location:354 → 458
      PCI; PCI domain
      pfam08375
      Location:461 → 519
      Rpn3_C; Proteasome regulatory subunit C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84139249..84151879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247272.4 → XP_006247334.1  26S proteasome non-ATPase regulatory subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNE7
      Conserved Domains (2) summary
      pfam01399
      Location:354 → 458
      PCI; PCI domain
      pfam08375
      Location:461 → 505
      Rpn3_C; Proteasome regulatory subunit C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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