Cdc6 cell division cycle 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc6provided by RGD
Official Full Name: cell division cycle 6provided by RGD
Primary source: RGD:1309157
See related: EnsemblRapid:ENSRNOG00000027787 AllianceGenome:RGD:1309157
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA replication origin binding activity; chromatin binding activity; and kinase binding activity. Involved in cellular response to peptide hormone stimulus; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and positive regulation of fibroblast proliferation. Predicted to be located in several cellular components, including intercellular bridge; nucleoplasm; and spindle. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 86.7), Spleen (RPKM 84.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84360361..84374239)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83864189..83878011)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86819477..86833301)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell division cycle 6 might play crucial roles in central nervous system pathophysiology after spinal cord injury.
Title: Expression of CDc6 after acute spinal cord injury in adult rats.
Activation of mTORC1 overrides the absence of the anchorage and stabilizes Cdc6 at least partly via activating Cdk4/6 that induces Emi1, an APC/C(Cdh1) ubiquitin ligase inhibitor.
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.
Cdc6 protein can activate p21-associated Cdk2 in an ATP-dependent manner in vitro.
Title: ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143256 (e-PCR)
- UniSTS:232503

BI286604 (e-PCR)
- UniSTS:245370

AW529160 (e-PCR)
- UniSTS:247265

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vasopressin	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell division control protein 6 homolog

Names: cell division cycle 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108298.1 → NP_001101768.1 cell division control protein 6 homolog

See identical proteins and their annotated locations for NP_001101768.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HIV7, D3ZRK7

Conserved Domains (1) summary

COG1474
Location:169 → 547

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

84360361..84374239

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247354.5 → XP_006247416.1 cell division control protein 6 homolog isoform X1

See identical proteins and their annotated locations for XP_006247416.1

UniProtKB/TrEMBL

A6HIV7, D3ZRK7

Related

ENSRNOP00000032177.4, ENSRNOT00000038228.6

Conserved Domains (1) summary

COG1474
Location:169 → 547

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
XM_006247355.5 → XP_006247417.1 cell division control protein 6 homolog isoform X2

Conserved Domains (3) summary

smart01074
Location:465 → 545

Cdc6_C; CDC6, C terminal

COG1474
Location:169 → 546

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13401
Location:196 → 326

AAA_22; AAA domain