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    2510002D24Rik RIKEN cDNA 2510002D24 gene [ Mus musculus (house mouse) ]

    Gene ID: 72307, updated on 27-Nov-2024

    Summary

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    Official Symbol
    2510002D24Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 2510002D24 geneprovided by MGI
    Primary source
    MGI:MGI:1919557
    See related
    Ensembl:ENSMUSG00000071632 AllianceGenome:MGI:1919557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pants; DXMgi27; 2410043I01Rik
    Summary
    Involved in negative regulation of long-term synaptic potentiation. Located in synapse and synaptic cleft. Is expressed in several structures, including brain; heart; liver; male reproductive gland or organ; and small intestine. Orthologous to human C22orf39 (chromosome 22 open reading frame 39). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 28.4), ovary adult (RPKM 25.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See 2510002D24Rik in Genome Data Viewer
    Location:
    16 A3; 16 11.67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18655263..18658910)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18836580..18840113)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 45 Neighboring gene predicted gene, 52240 Neighboring gene STARR-positive B cell enhancer ABC_E763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18812268-18812501 Neighboring gene ubiquitin recognition factor in ER-associated degradation 1 Neighboring gene STARR-positive B cell enhancer ABC_E10892 Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene histone cell cycle regulator Neighboring gene 60S ribosomal protein L27a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region. Kragness S, et al. Gene Expr Patterns, 2018 Jun. PMID 29571919
    2. An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age. Kragness S, et al. PLoS One, 2022. PMID 35771867, Free PMC Article
    3. Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium. Devaraju P, et al. Mol Psychiatry, 2017 Sep. PMID 27184122, Free PMC Article
    4. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2. Lund J, et al. Genomics, 2000 Feb 1. PMID 10704284
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptic plasticity regulator PANTS
    Names
    UPF0545 protein C22orf39 homolog
    plasticity-associated neural transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033164.2 → NP_001028336.1  synaptic plasticity regulator PANTS

      See identical proteins and their annotated locations for NP_001028336.1

      Status: VALIDATED

      Source sequence(s)
      AK153794, AK160192
      Consensus CDS
      CCDS28029.1
      UniProtKB/Swiss-Prot
      Q3U595
      Related
      ENSMUSP00000060363.7, ENSMUST00000055413.13
      Conserved Domains (1) summary
      pfam11326
      Location:13 → 88
      DUF3128; Protein of unknown function (DUF3128)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18655263..18658910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160137.1 → XP_036016030.1  synaptic plasticity regulator PANTS isoform X1

      UniProtKB/TrEMBL
      A0A087WS89
      Related
      ENSMUSP00000140943.2, ENSMUST00000123146.8
      Conserved Domains (1) summary
      pfam11326
      Location:23 → 74
      DUF3128; Protein of unknown function (DUF3128)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U595.1 GenPept UniProtKB/Swiss-Prot:Q3U595

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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