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    Nsd1 nuclear receptor-binding SET-domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 18193, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nsd1provided by MGI
    Official Full Name
    nuclear receptor-binding SET-domain protein 1provided by MGI
    Primary source
    MGI:MGI:1276545
    See related
    Ensembl:ENSMUSG00000021488 AllianceGenome:MGI:1276545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT3B
    Summary
    Enables several functions, including nuclear receptor binding activity; protein-lysine N-methyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within gastrulation with mouth forming second. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; long bone epiphysis; and retina. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.4), placenta adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nsd1 in Genome Data Viewer
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55357595..55466138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55209782..55318325)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E5399 Neighboring gene STARR-seq mESC enhancer starr_34607 Neighboring gene STARR-seq mESC enhancer starr_34609 Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene Max dimerization protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons. Hamagami N, et al. Mol Cell, 2023 May 4. PMID 37098340, Free PMC Article
    2. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression. Fang Y, et al. Nucleic Acids Res, 2021 Jun 21. PMID 34107030, Free PMC Article
    3. Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1. Oishi S, et al. Genes Brain Behav, 2020 Apr. PMID 31909872
    4. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis. Shao R, et al. Cell Death Differ, 2024 Jan. PMID 38012390,
    5. Molecular characterization of NSD1, a human homologue of the mouse Nsd1 gene. Kurotaki N, et al. Gene, 2001 Nov 28. PMID 11733144

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
      Title: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
    2. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
      Title: H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
    3. Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.
      Title: Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.
    4. Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
      Title: Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
    5. NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
      Title: NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
    6. H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.
      Title: H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.
    7. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression.
      Title: The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression.
    8. Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1.
      Title: Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1.
    9. NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing.
      Title: NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing.
    10. Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
      Title: Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables histone H4K20 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear androgen receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone methyltransferase complex IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-36 specific
    Names
    H3-K36-HMTase
    H4-K20-HMTase
    NR-binding SET domain-containing protein
    histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    nuclear receptor-binding SET domain-containing protein 1
    NP_001395627.1
    NP_001395628.1
    NP_001395629.1
    NP_001395630.1
    NP_001395631.1
    NP_001395632.1
    NP_001395633.1
    NP_001395634.1
    NP_001395635.1
    NP_001395636.1
    NP_001395637.1
    NP_001395638.1
    NP_001395639.1
    NP_001395640.1
    NP_001395641.1
    NP_001395642.1
    NP_001395643.1
    NP_001395644.1
    NP_032765.3
    XP_006517197.1
    XP_006517198.1
    XP_006517199.1
    XP_006517200.1
    XP_006517201.1
    XP_006517203.1
    XP_006517204.1
    XP_006517205.1
    XP_006517207.1
    XP_006517209.1
    XP_006517210.1
    XP_006517211.1
    XP_030103041.1
    XP_030103042.1
    XP_030103044.1
    XP_030103046.1
    XP_030103047.1
    XP_036013798.1
    XP_036013799.1
    XP_036013800.1
    XP_036013801.1
    XP_036013802.1
    XP_036013803.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408698.1 → NP_001395627.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160958

    2. NM_001408699.1 → NP_001395628.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160958

    3. NM_001408700.1 → NP_001395629.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160958

    4. NM_001408701.1 → NP_001395630.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC160958

    5. NM_001408702.1 → NP_001395631.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160958

    6. NM_001408703.1 → NP_001395632.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160958

    7. NM_001408704.1 → NP_001395633.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160958

    8. NM_001408705.1 → NP_001395634.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160958

    9. NM_001408706.1 → NP_001395635.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC160958

    10. NM_001408707.1 → NP_001395636.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC160958

    11. NM_001408708.1 → NP_001395637.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC160958

    12. NM_001408709.1 → NP_001395638.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160958
      UniProtKB/TrEMBL
      A0A286YDS9

    13. NM_001408710.1 → NP_001395639.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160958
      UniProtKB/TrEMBL
      A0A286YDS9

    14. NM_001408711.1 → NP_001395640.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160958
      UniProtKB/TrEMBL
      A0A286YDS9
      Related
      ENSMUSP00000152939.2, ENSMUST00000224693.2

    15. NM_001408712.1 → NP_001395641.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160958
      UniProtKB/TrEMBL
      A0A286YDS9
      Related
      ENSMUSP00000153511.2, ENSMUST00000224918.2

    16. NM_001408713.1 → NP_001395642.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC160958

    17. NM_001408714.1 → NP_001395643.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC160958

    18. NM_001408715.1 → NP_001395644.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC160958

    19. NM_008739.3 → NP_032765.3  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 1

      See identical proteins and their annotated locations for NP_032765.3

      Status: VALIDATED

      Source sequence(s)
      AC160958, AK145783, BI737132, BQ442794, BQ917954, CA318563, CB247038, CD549506, CD806124, CN529078
      Consensus CDS
      CCDS36673.1
      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Related
      ENSMUSP00000097089.3, ENSMUST00000099490.3
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55357595..55466138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517146.3 → XP_006517209.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      See identical proteins and their annotated locations for XP_006517209.1

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    2. XM_030247184.2 → XP_030103044.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    3. XM_006517138.5 → XP_006517201.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517201.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    4. XM_006517144.3 → XP_006517207.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      See identical proteins and their annotated locations for XP_006517207.1

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    5. XM_006517137.4 → XP_006517200.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517200.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    6. XM_036157908.1 → XP_036013801.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (11) summary
      cd05838
      Location:1370 → 1464
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1870 → 2191
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1068 → 1202
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1161 → 1202
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1208 → 1254
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1255 → 1308
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1325 → 1364
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1736 → 1778
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1557 → 1698
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1517 → 1555
      AWS; AWS domain
      pfam17982
      Location:1777 → 1826
      C5HCH; NSD Cys-His rich domain

    7. XM_030247181.2 → XP_030103041.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    8. XM_006517140.5 → XP_006517203.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517203.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    9. XM_036157910.1 → XP_036013803.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (11) summary
      cd05838
      Location:1370 → 1464
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1870 → 2191
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1068 → 1202
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1161 → 1202
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1208 → 1254
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1255 → 1308
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1325 → 1364
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1736 → 1778
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1557 → 1698
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1517 → 1555
      AWS; AWS domain
      pfam17982
      Location:1777 → 1826
      C5HCH; NSD Cys-His rich domain

    10. XM_030247186.2 → XP_030103046.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    11. XM_006517148.4 → XP_006517211.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X4

      Conserved Domains (10) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      cl22851
      Location:2121 → 2155
      PHD_SF; PHD finger superfamily

    12. XM_006517136.4 → XP_006517199.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517199.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    13. XM_006517134.5 → XP_006517197.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517197.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    14. XM_006517135.5 → XP_006517198.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517198.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    15. XM_036157906.1 → XP_036013799.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (11) summary
      cd05838
      Location:1370 → 1464
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1870 → 2191
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1068 → 1202
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1161 → 1202
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1208 → 1254
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1255 → 1308
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1325 → 1364
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1736 → 1778
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1557 → 1698
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1517 → 1555
      AWS; AWS domain
      pfam17982
      Location:1777 → 1826
      C5HCH; NSD Cys-His rich domain

    16. XM_036157907.1 → XP_036013800.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (11) summary
      cd05838
      Location:1370 → 1464
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1870 → 2191
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1068 → 1202
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1161 → 1202
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1208 → 1254
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1255 → 1308
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1325 → 1364
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1736 → 1778
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1557 → 1698
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1517 → 1555
      AWS; AWS domain
      pfam17982
      Location:1777 → 1826
      C5HCH; NSD Cys-His rich domain

    17. XM_030247182.2 → XP_030103042.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    18. XM_030247187.2 → XP_030103047.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X5

      Conserved Domains (9) summary
      cd05838
      Location:230 → 324
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:730 → 1051
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15648
      Location:21 → 62
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15653
      Location:115 → 168
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:596 → 638
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:377 → 415
      AWS; AWS domain
      pfam17982
      Location:637 → 686
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:417 → 558
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      cl22851
      Location:68 → 114
      PHD_SF; PHD finger superfamily

    19. XM_006517147.3 → XP_006517210.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      See identical proteins and their annotated locations for XP_006517210.1

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    20. XM_036157909.1 → XP_036013802.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (11) summary
      cd05838
      Location:1370 → 1464
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1870 → 2191
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1068 → 1202
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1161 → 1202
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1208 → 1254
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1255 → 1308
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1325 → 1364
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1736 → 1778
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1557 → 1698
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1517 → 1555
      AWS; AWS domain
      pfam17982
      Location:1777 → 1826
      C5HCH; NSD Cys-His rich domain

    21. XM_006517142.5 → XP_006517205.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517205.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    22. XM_006517141.3 → XP_006517204.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006517204.1

      UniProtKB/TrEMBL
      A0A286YE36, E9QAE4
      Conserved Domains (12) summary
      cd05837
      Location:320 → 430
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1755 → 1849
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:2255 → 2576
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1453 → 1587
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1546 → 1587
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1593 → 1639
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1640 → 1693
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1710 → 1749
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2121 → 2163
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      pfam17907
      Location:1902 → 1940
      AWS; AWS domain
      pfam17982
      Location:2162 → 2211
      C5HCH; NSD Cys-His rich domain
      cd19210
      Location:1942 → 2083
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

    23. XM_036157905.1 → XP_036013798.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A286YE36
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1485 → 1579
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03307
      Location:1985 → 2306
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5034
      Location:1183 → 1317
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1276 → 1317
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1323 → 1369
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1370 → 1423
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1440 → 1479
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1851 → 1893
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1672 → 1813
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1632 → 1670
      AWS; AWS domain
      pfam17982
      Location:1892 → 1941
      C5HCH; NSD Cys-His rich domain

    RNA

    1. XR_382424.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88491.1 GenPept UniProtKB/Swiss-Prot:O88491

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