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    Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [ Mus musculus (house mouse) ]

    Gene ID: 13480, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpm1provided by MGI
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by MGI
    Primary source
    MGI:MGI:1330239
    See related
    Ensembl:ENSMUSG00000078919 AllianceGenome:MGI:1330239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables dolichyl-phosphate beta-D-mannosyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process; dolichol metabolic process; and response to oxygen levels. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.1), bladder adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpm1 in Genome Data Viewer
    Location:
    2 H3; 2 88.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168050968..168072299, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168209048..168230379, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54130 Neighboring gene predicted gene 20716 Neighboring gene activity-dependent neuroprotective protein Neighboring gene STARR-seq mESC enhancer starr_06457 Neighboring gene STARR-positive B cell enhancer ABC_E10163 Neighboring gene STARR-positive B cell enhancer ABC_E8797 Neighboring gene STARR-seq mESC enhancer starr_06458 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ebz of NZW mice is identical with Ebu of B10.PL mice. Nishimura H, et al. Immunogenetics, 1991. PMID 2050394
    2. Nucleotide sequence analysis of MHC class II genes in autoimmune disease-prone (NZB x NZW)F1 mice. Ogawa S, et al. Immunogenetics, 1990. PMID 2165036
    3. Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion. Gao J, et al. Clin Proteomics, 2014. PMID 24936167, Free PMC Article
    4. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. Tomita S, et al. J Biol Chem, 1998 Apr 10. PMID 9535917
    5. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Mallakin A, et al. Cancer Cell, 2007 Oct. PMID 17936562, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm20716

    Readthrough gene: Gm20716, Included gene: Adnp

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-mannose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl-phosphate beta-D-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within dolichol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol phosphate mannose biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to oxygen levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dolichol-phosphate mannosyltransferase subunit 1
    Names
    DPM synthase subunit 1
    MPD synthase
    dolichol-phosphate (beta-D) mannosyltransferase 1
    dolichol-phosphate mannose synthase subunit 1
    dolichyl-phosphate beta-D-mannosyltransferase subunit 1
    mannose-P-dolichol synthase subunit 1
    NP_001297013.1
    NP_034202.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310084.1 → NP_001297013.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK004834, BF019794, BM941163, BX005039
      UniProtKB/Swiss-Prot
      O70152
      Conserved Domains (2) summary
      cd06442
      Location:29 → 233
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:21 → 237
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

    2. NM_010072.4 → NP_034202.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_034202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK005268, BM941163, BX005039
      Consensus CDS
      CCDS17109.1
      UniProtKB/Swiss-Prot
      O70152, Q9D829
      Related
      ENSMUSP00000118776.2, ENSMUST00000154111.8
      Conserved Domains (2) summary
      cd06442
      Location:29 → 256
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:21 → 260
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168050968..168072299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70152.1 GenPept UniProtKB/Swiss-Prot:O70152

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