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    Hivep1 HIVEP zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117140, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hivep1provided by RGD
    Official Full Name
    HIVEP zinc finger 1provided by RGD
    Primary source
    RGD:727847
    See related
    EnsemblRapid:ENSRNOG00000014460 AllianceGenome:RGD:727847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA binding activity. Predicted to be involved in BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; mitochondrion; and nuclear body. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 81.1), Lung (RPKM 63.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hivep1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (22790855..22920359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (22585016..22714517, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22278103..22403362, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene endothelin 1 Neighboring gene uncharacterized LOC102548003 Neighboring gene uncharacterized LOC120097876 Neighboring gene uncharacterized LOC108348545 Neighboring gene uncharacterized LOC134482771 Neighboring gene uncharacterized LOC134482838

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of two cDNAs encoding zinc finger proteins which bind to the alpha 1-antitrypsin promoter and to the major histocompatibility complex class I enhancer. Mitchelmore C, et al. Nucleic Acids Res, 1991 Jan 11. PMID 1901405, Free PMC Article
    2. Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1. Yu B, et al. Exp Cell Res, 2009 Nov 1. PMID 19732766
    3. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang X, et al. J Biol Chem, 2005 May 13. PMID 15778499
    4. Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism. Yao LC, et al. Development, 2006 Oct. PMID 17008448
    5. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissmüller S, et al. Nucleic Acids Res, 2006. PMID 16582099, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables HMG box domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 40
    Names
    human immunodeficiency virus type I enhancer binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105751.2 → NP_001099221.2  zinc finger protein 40

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (4) summary
      smart00355
      Location:2100 → 2121
      ZnF_C2H2; zinc finger
      PHA03247
      Location:2272 → 2662
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2074 → 2094
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      22790855..22920359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095309.2 → XP_038951237.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (6) summary
      PHA03247
      Location:2273 → 2663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2075 → 2095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2073 → 2095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:2101 → 2166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039095308.1 → XP_038951236.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (6) summary
      PHA03247
      Location:2273 → 2663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2075 → 2095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2073 → 2095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:2101 → 2166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039095310.1 → XP_038951238.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Related
      ENSRNOP00000019389.8, ENSRNOT00000019389.9
      Conserved Domains (6) summary
      PHA03247
      Location:2273 → 2663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2075 → 2095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2073 → 2095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:2101 → 2166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    4. XM_063276029.1 → XP_063132099.1  zinc finger protein 40 isoform X2

      UniProtKB/TrEMBL
      F1M9H4

    5. XM_063276031.1 → XP_063132101.1  zinc finger protein 40 isoform X4

    6. XM_063276030.1 → XP_063132100.1  zinc finger protein 40 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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