Mapk6 mitogen-activated protein kinase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk6provided by RGD
Official Full Name: mitogen-activated protein kinase 6provided by RGD
Primary source: RGD:62087
See related: EnsemblRapid:ENSRNOG00000009381 AllianceGenome:RGD:62087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ERK3
Summary: Predicted to enable MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 315.1), Testes (RPKM 287.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85027141..85050236, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76146650..76169767, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82328013..82351108, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-beta1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6.
Title: TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6.
analysis revealed that the effects of miR-26a in VSMCs were mediated by targeting MAPK6 at the mRNA and protein levels.
Title: MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
miR-26a-5p could act as a negative regulator of neuropathic pain development through targeting MAPK6
Title: Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models.
Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury.
Title: Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.
It plays distinct role in proliferation, differentiation, and neuronal viability.
Title: Role of ERK1, 2, and 5 in dopamine neuron survival during aging.
These data suggest a novel mechanism for the localization of an MAPK family member, ERK3, in which cell cycle-regulated, site-specific proteolysis generates the nuclear form of the protein.
Title: A novel mechanism for mitogen-activated protein kinase localization.
ERK3 biological activity is regulated by its cellular abundance through the control of protein stability
Title: Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
MAP2 is involved in ERK3 mediated insulin secretion
Title: ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion.

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General gene information

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Markers

AW555821 (e-PCR)
- UniSTS:208421

AW521769 (e-PCR)
- UniSTS:261681

MAPK6_180.2 (e-PCR)
- UniSTS:462333

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in septin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 6

Names: ERK-3; MAP kinase 6; MAPK 6; extracellular signal-regulated kinase 3; p55-MAPK

NP_113810.2

EC 2.7.11.24

XP_006243471.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031622.2 → NP_113810.2 mitogen-activated protein kinase 6

See identical proteins and their annotated locations for NP_113810.2

Status: VALIDATED

Source sequence(s)

BC109380, BE104187, CB742965

UniProtKB/Swiss-Prot

P27704, Q32LY4

UniProtKB/TrEMBL

A6I1C7

Related

ENSRNOP00000013053.3, ENSRNOT00000013053.8

Conserved Domains (2) summary

cd07854
Location:14 → 355

STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

smart00220
Location:20 → 316

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

85027141..85050236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243409.5 → XP_006243471.1 mitogen-activated protein kinase 6 isoform X1

See identical proteins and their annotated locations for XP_006243471.1

UniProtKB/Swiss-Prot

P27704, Q32LY4

UniProtKB/TrEMBL

A6I1C7

Conserved Domains (2) summary

cd07854
Location:14 → 355

STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

smart00220
Location:20 → 316

S_TKc; Serine/Threonine protein kinases, catalytic domain