PDC5 indolepyruvate decarboxylase 5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PDC5
Official Full Name: indolepyruvate decarboxylase 5
Primary source: SGD:S000004124
Locus tag: YLR134W
See related: AllianceGenome:SGD:S000004124; FungiDB:YLR134W; VEuPathDB:YLR134W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables branched-chain-2-oxoacid decarboxylase activity and pyruvate decarboxylase activity. Involved in aromatic amino acid family catabolic process; glycolytic fermentation to ethanol; and pyruvate metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PDC5 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (410723..412414)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of pyruvate decarboxylase (pdc1, pdc5) gene knockout on the production of metabolites in two haploid Saccharomyces cerevisiae strains.
Title: Effects of pyruvate decarboxylase (pdc1, pdc5) gene knockout on the production of metabolites in two haploid Saccharomyces cerevisiae strains.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables branched-chain-2-oxoacid decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-2-oxoacid decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables indolepyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate decarboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid catabolic process via Ehrlich pathway	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branched-chain amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic fermentation to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic fermentation to ethanol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pyruvate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: indolepyruvate decarboxylase 5

NP_013235.1

EC 4.1.1.43

EC 4.1.1.72

EC 4.1.1.74

Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

410723..412414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182021.1 → NP_013235.1 TPA: indolepyruvate decarboxylase 5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYC9, P16467

UniProtKB/TrEMBL

A7A133, B3LT95, C8ZDA3, G2WIX3

Conserved Domains (1) summary

COG3961
Location:1 → 563

PDC1; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]