Ipo5 importin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipo5provided by MGI
Official Full Name: importin 5provided by MGI
Primary source: MGI:MGI:1917822
See related: Ensembl:ENSMUSG00000030662 AllianceGenome:MGI:1917822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMB3; imp5; Kpnb3; Ranbp5; 1110011C18Rik; 5730478E03Rik
Summary: Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; cellular response to amino acid stimulus; and positive regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in cerebral cortex and gonad. Orthologous to human IPO5 (importin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 96.4), CNS E11.5 (RPKM 33.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E4- E5; 14 64.81 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (121134271..121185451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (120896840..120948046)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.
Title: IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.
nuclear import protein IPO5 facilitates the nuclear translocation of MSI1 to the transcriptionally silenced XY chromatin domain in meiotic pachytene spermatocytes, resulting in the release of MSI1 RNA-binding targets
Title: RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.
RanBP5 exhibits age- and gender-specific subcellular localization within fetal gonads. At E12.5, RanBP5 protein is cytoplasmic in gonocytes but predominantly nuclear in oogonia, but by E14.5 RanBP5 appears nuclear in gonocytes and cytoplasmic in oogonia
Title: Subcellular distribution of importins correlates with germ cell maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C76941 (e-PCR)
- UniSTS:160895

RH124842 (e-PCR)
- UniSTS:161664

RH130384 (e-PCR)
- UniSTS:213668

RH126066 (e-PCR)
- UniSTS:162778

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: importin-5

Names: RAN binding protein 5; importin beta 3; importin subunit beta-3; karyopherin (importin) beta 3; karyopherin beta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416269.1 → NP_001403198.1 importin-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC154283

Related

ENSMUST00000228277.2
NM_001416270.1 → NP_001403199.1 importin-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC154283
NM_001416271.1 → NP_001403200.1 importin-5 isoform 1

Status: VALIDATED

Source sequence(s)

AC154283

UniProtKB/Swiss-Prot

Q3TEG2, Q7TQC6, Q8BKC5, Q9EQ30
NM_001416272.1 → NP_001403201.1 importin-5 isoform 1

Status: VALIDATED

Source sequence(s)

AC154283

UniProtKB/Swiss-Prot

Q3TEG2, Q7TQC6, Q8BKC5, Q9EQ30
NM_001416274.1 → NP_001403203.1 importin-5 isoform 3

Status: VALIDATED

Source sequence(s)

AC154283
NM_023579.5 → NP_076068.1 importin-5 isoform 1

See identical proteins and their annotated locations for NP_076068.1

Status: VALIDATED

Source sequence(s)

AC154283

Consensus CDS

CCDS37014.1

UniProtKB/Swiss-Prot

Q3TEG2, Q7TQC6, Q8BKC5, Q9EQ30

Related

ENSMUSP00000032898.8, ENSMUST00000032898.9

Conserved Domains (6) summary

COG5215
Location:13 → 634

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:355 → 387

HEAT; HEAT repeat [structural motif]

pfam13513
Location:921 → 966

HEAT_EZ; HEAT-like repeat

pfam18808
Location:268 → 357

Importin_rep_4; Importin repeat

pfam18816
Location:1005 → 1051

Importin_rep_5; Importin repeat

pfam18829
Location:765 → 874

Importin_rep_6; Importin repeat 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

121134271..121185451

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248019.2 → XP_030103879.1 importin-5 isoform X1

UniProtKB/Swiss-Prot

Q3TEG2, Q7TQC6, Q8BKC5, Q9EQ30

Conserved Domains (6) summary

COG5215
Location:13 → 634

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:355 → 387

HEAT; HEAT repeat [structural motif]

pfam13513
Location:921 → 966

HEAT_EZ; HEAT-like repeat

pfam18808
Location:268 → 357

Importin_rep_4; Importin repeat

pfam18816
Location:1005 → 1051

Importin_rep_5; Importin repeat

pfam18829
Location:765 → 874

Importin_rep_6; Importin repeat 6