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    EFR3 Efr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EFR3
    Official Full Name
    Efr3p
    Primary source
    SGD:S000004825
    Locus tag
    YMR212C
    See related
    AllianceGenome:SGD:S000004825; FungiDB:YMR212C; VEuPathDB:YMR212C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein localization to plasma membrane. Located in plasma membrane. Used to study autism spectrum disorder. Orthologous to human EFR3A (EFR3 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EFR3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (690695..693043, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative carboxylic ester hydrolase Neighboring gene Dml1p Neighboring gene Cef1p Neighboring gene Scj1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rare deleterious mutations of the gene EFR3A in autism spectrum disorders. Gupta AR, et al. Mol Autism, 2014. PMID 24860643, Free PMC Article
    2. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Wu X, et al. Dev Cell, 2014 Jan 13. PMID 24360784, Free PMC Article
    3. Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. Baird D, et al. J Cell Biol, 2008 Dec 15. PMID 19075114, Free PMC Article
    4. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article
    5. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Lenburg ME, et al. Genetics, 2001 Jan. PMID 11139490, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Efr3 C terminus phosphorylation regulates phosphatidylinositol 4-kinase complex assembly and plasma membrane targeting.
      Title: Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.
    2. Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately plasma membrane-based PtdIns4P signaling.
      Title: Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Efr3p
    NP_013939.1
    • Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      690695..693043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182719.1 → NP_013939.1  TPA: Efr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W037, Q03653
      UniProtKB/TrEMBL
      B3LMA0, C7GRD9, C8ZF76
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03653.1

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