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    Tmem183a transmembrane protein 183A [ Mus musculus (house mouse) ]

    Gene ID: 57439, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem183aprovided by MGI
    Official Full Name
    transmembrane protein 183Aprovided by MGI
    Primary source
    MGI:MGI:1914729
    See related
    Ensembl:ENSMUSG00000042305 AllianceGenome:MGI:1914729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem183; 1300007B12Rik; 1700020N19Rik
    Summary
    Predicted to be involved in regulation of protein stability. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to several human genes including TMEM183A (transmembrane protein 183A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 21.3), CNS E18 (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem183a in Genome Data Viewer
    Location:
    1 E4; 1 58.2 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134273834..134289765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134346096..134362012, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene myogenin Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Neighboring gene predicted gene, 32267 Neighboring gene STARR-seq mESC enhancer starr_02324 Neighboring gene predicted gene, 53477 Neighboring gene STARR-seq mESC enhancer starr_02326 Neighboring gene MGAT4 family, member F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 183

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042485.1 → NP_001035950.1  transmembrane protein 183 isoform b

      See identical proteins and their annotated locations for NP_001035950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AK013009, AK152852, BY142931, CF897336
      UniProtKB/Swiss-Prot
      Q9JJB9
      UniProtKB/TrEMBL
      Q9CSF0

    2. NM_020588.2 → NP_065613.1  transmembrane protein 183 isoform a

      See identical proteins and their annotated locations for NP_065613.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AK013009, AK152852, BY142931
      Consensus CDS
      CCDS35714.1
      UniProtKB/Swiss-Prot
      Q3THC8, Q99LK6, Q9JJB9
      Related
      ENSMUSP00000046786.5, ENSMUST00000049470.11

    RNA

    1. NR_151737.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124110

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134273834..134289765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003956268.2 RNA Sequence

    2. XR_004933981.1 RNA Sequence

    3. XR_003956269.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJB9.1 GenPept UniProtKB/Swiss-Prot:Q9JJB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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