H2bc22 H2B clustered histone 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2bc22provided by MGI
Official Full Name: H2B clustered histone 22provided by MGI
Primary source: MGI:MGI:2448409
See related: Ensembl:ENSMUSG00000069308 AllianceGenome:MGI:2448409
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hist1h2bp
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
Expression: Broad expression in thymus adult (RPKM 257.9), colon adult (RPKM 133.4) and 23 other tissues See more
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Genomic context

Location:: 13 A3.1; 13 7.97 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (21971652..21985731)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (21787483..21801561)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hist1h2bc (e-PCR), detects polymorphism
- UniSTS:259084

M25487 (e-PCR)
- UniSTS:124947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H2B type 1-P

Names: histone 1, H2bp; histone cluster 1, H2bp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290466.1 → NP_001277395.1 histone H2B type 1-P isoform 2

See identical proteins and their annotated locations for NP_001277395.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal and tail, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.

Source sequence(s)

AL589651

Consensus CDS

CCDS79168.1

UniProtKB/Swiss-Prot

Q64477, Q6P8V8, Q8CGP2

UniProtKB/TrEMBL

A0JLV3

Related

ENSMUSP00000100047.2, ENSMUST00000102982.2

Conserved Domains (1) summary

smart00427
Location:28 → 124

H2B; Histone H2B
NM_178202.2 → NP_835509.2 histone H2B type 1-P isoform 1

See identical proteins and their annotated locations for NP_835509.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AV047260, BC061044

Consensus CDS

CCDS26298.2

UniProtKB/TrEMBL

A0JLV3

Related

ENSMUSP00000106099.3, ENSMUST00000110473.3

Conserved Domains (2) summary

pfam00125
Location:3 → 102

Histone; Core histone H2A/H2B/H3/H4

cl23830
Location:12 → 125

H2B; Histone H2B