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    Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 54342, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gnpnat1provided by MGI
    Official Full Name
    glucosamine-phosphate N-acetyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1858963
    See related
    Ensembl:ENSMUSG00000037722 AllianceGenome:MGI:1858963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMeg32; Gpnat1; Gsnpat
    Summary
    Enables glucosamine 6-phosphate N-acetyltransferase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.7), liver E18 (RPKM 6.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gnpnat1 in Genome Data Viewer
    Location:
    14 C1; 14 22.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45613897..45626972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45376421..45388987, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene STARR-seq mESC enhancer starr_36535 Neighboring gene predicted gene, 41143 Neighboring gene STARR-seq mESC enhancer starr_36537 Neighboring gene predicted gene, 34250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association. Boehmelt G, et al. J Biol Chem, 2000 Apr 28. PMID 10777580
    2. Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. Boehmelt G, et al. EMBO J, 2000 Oct 2. PMID 11013212, Free PMC Article
    3. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. Inohara N, et al. J Biol Chem, 1998 Apr 10. PMID 9535847
    4. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
    5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucosamine 6-phosphate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucosamine 6-phosphate N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucosamine 6-phosphate N-acetyltransferase
    Names
    glucosamine-6-phosphate acetyltransferase
    glucosamine-phosphate N-acetyltransferase 1; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase
    phosphoglucosamine acetylase
    phosphoglucosamine transacetylase
    NP_001404467.1
    NP_001404468.1
    NP_001404469.1
    NP_001404470.1
    NP_001404471.1
    NP_001404472.1
    NP_001404473.1
    NP_001404474.1
    NP_001404475.1
    NP_001404476.1
    NP_001404478.1
    NP_001404479.1
    NP_062298.1
    XP_036014653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417538.1 → NP_001404467.1  glucosamine 6-phosphate N-acetyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      A0A2I3BQY4
      Related
      ENSMUSP00000154382.2, ENSMUST00000226276.2

    2. NM_001417539.1 → NP_001404468.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025535

    3. NM_001417540.1 → NP_001404469.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025535

    4. NM_001417541.1 → NP_001404470.1  glucosamine 6-phosphate N-acetyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025535

    5. NM_001417542.1 → NP_001404471.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38

    6. NM_001417543.1 → NP_001404472.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38

    7. NM_001417544.1 → NP_001404473.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38

    8. NM_001417545.1 → NP_001404474.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38

    9. NM_001417546.1 → NP_001404475.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38

    10. NM_001417547.1 → NP_001404476.1  glucosamine 6-phosphate N-acetyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025535

    11. NM_001417549.1 → NP_001404478.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT025535
      Related
      ENSMUSP00000154777.2, ENSMUST00000227865.2

    12. NM_001417550.1 → NP_001404479.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT025535

    13. NM_019425.3 → NP_062298.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      See identical proteins and their annotated locations for NP_062298.1

      Status: VALIDATED

      Source sequence(s)
      CT025535
      Consensus CDS
      CCDS26976.1
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
      Related
      ENSMUSP00000042860.8, ENSMUST00000046191.9
      Conserved Domains (1) summary
      cl17182
      Location:36 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      45613897..45626972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158760.1 → XP_036014653.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
      Conserved Domains (1) summary
      cl17182
      Location:36 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK38.1 GenPept UniProtKB/Swiss-Prot:Q9JK38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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