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    Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Mus musculus (house mouse) ]

    Gene ID: 13481, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpm2provided by MGI
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by MGI
    Primary source
    MGI:MGI:1330238
    See related
    Ensembl:ENSMUSG00000026810 AllianceGenome:MGI:1330238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process; dolichol metabolic process; and regulation of protein stability. Predicted to be located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Predicted to be part of dolichol-phosphate-mannose synthase complex and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.3), large intestine adult (RPKM 53.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpm2 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32460870..32463583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32570858..32573571)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. Maeda Y, et al. EMBO J, 1998 Sep 1. PMID 9724629, Free PMC Article
    2. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Lennon G, et al. Genomics, 1996 Apr 1. PMID 8617505
    3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
    4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
    5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dolichol-phosphate-mannose synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dolichol phosphate-mannose biosynthesis regulatory protein
    Names
    DPM synthase subunit 2
    dolichol-phosphate (beta-D) mannosyltransferase 2
    dolichol-phosphate mannose synthase subunit 2
    NP_034203.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010073.2 → NP_034203.1  dolichol phosphate-mannose biosynthesis regulatory protein

      See identical proteins and their annotated locations for NP_034203.1

      Status: VALIDATED

      Source sequence(s)
      BC008256
      Consensus CDS
      CCDS38104.1
      UniProtKB/Swiss-Prot
      Q9Z324
      UniProtKB/TrEMBL
      Q545R7
      Related
      ENSMUSP00000028151.7, ENSMUST00000028151.7
      Conserved Domains (1) summary
      pfam07297
      Location:5 → 78
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32460870..32463583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z324.3 GenPept UniProtKB/Swiss-Prot:Q9Z324

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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