Rdh13 retinol dehydrogenase 13 (all-trans and 9-cis) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdh13provided by MGI
Official Full Name: retinol dehydrogenase 13 (all-trans and 9-cis)provided by MGI
Primary source: MGI:MGI:1918732
See related: Ensembl:ENSMUSG00000008435 AllianceGenome:MGI:1918732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8430425D21Rik
Summary: Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Acts upstream of or within eye photoreceptor cell development; response to high light intensity; and retina layer formation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 8.9), whole brain E14.5 (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.56 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4428664..4474279, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4425665..4471280, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggested that the alleviated liver damage induced by CCl4 in Rdh13(-/-) mice was caused by Cyp2e1 enzymes, which promoted reductive CCl4 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury.
Title: Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels.
Rdh13 can protect the retina against acute light-induced retinopathy.
Title: Retinol dehydrogenase 13 protects the mouse retina from acute light damage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rdh13 (e-PCR), detects polymorphism
- UniSTS:507187

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to high light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: retinol dehydrogenase 13

NP_001277338.1

EC 1.1.1.300

NP_001277340.1

EC 1.1.1.300

NP_780581.1

EC 1.1.1.300

XP_011248714.1

EC 1.1.1.300

XP_030097836.1

EC 1.1.1.300

XP_030097837.1

EC 1.1.1.300

XP_030097838.1

EC 1.1.1.300

XP_030097839.1

EC 1.1.1.300

XP_030097840.1

EC 1.1.1.300

XP_030097841.1

EC 1.1.1.300

XP_036008457.1

EC 1.1.1.300

XP_036008458.1

EC 1.1.1.300

XP_036008459.1

EC 1.1.1.300

XP_036008460.1

EC 1.1.1.300

XP_036008461.1

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290409.1 → NP_001277338.1 retinol dehydrogenase 13 isoform 2 precursor

See identical proteins and their annotated locations for NP_001277338.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC161218, AK034180, BY083213

UniProtKB/TrEMBL

A0A0R4J1N8

Related

ENSMUSP00000113433.2, ENSMUST00000119485.8

Conserved Domains (2) summary

PRK06197
Location:32 → 283

PRK06197; short chain dehydrogenase; Provisional

cl21454
Location:38 → 278

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001290411.1 → NP_001277340.1 retinol dehydrogenase 13 isoform 3

See identical proteins and their annotated locations for NP_001277340.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC161218, AK028434, BY083213, BY352329

UniProtKB/Swiss-Prot

Q8CEE7

Conserved Domains (1) summary

cl21454
Location:1 → 242

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_175372.4 → NP_780581.1 retinol dehydrogenase 13 isoform 1 precursor

See identical proteins and their annotated locations for NP_780581.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC161218, AK028434

Consensus CDS

CCDS20735.1

UniProtKB/Swiss-Prot

Q8CC07, Q8CEE7

Related

ENSMUSP00000008579.8, ENSMUST00000008579.14

Conserved Domains (1) summary

cl21454
Location:38 → 313

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4428664..4474279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250412.3 → XP_011248714.1 retinol dehydrogenase 13 isoform X2

Conserved Domains (1) summary

cl21454
Location:18 → 293

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036152564.1 → XP_036008457.1 retinol dehydrogenase 13 isoform X1

UniProtKB/Swiss-Prot

Q8CC07, Q8CEE7

Conserved Domains (1) summary

cl21454
Location:38 → 313

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241979.1 → XP_030097839.1 retinol dehydrogenase 13 isoform X5

Conserved Domains (1) summary

cl21454
Location:1 → 207

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241978.1 → XP_030097838.1 retinol dehydrogenase 13 isoform X4

Conserved Domains (1) summary

cl21454
Location:1 → 242

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241981.1 → XP_030097841.1 retinol dehydrogenase 13 isoform X5

Conserved Domains (1) summary

cl21454
Location:1 → 207

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036152567.1 → XP_036008460.1 retinol dehydrogenase 13 isoform X4

Conserved Domains (1) summary

cl21454
Location:1 → 242

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036152568.1 → XP_036008461.1 retinol dehydrogenase 13 isoform X4

Conserved Domains (1) summary

cl21454
Location:1 → 242

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241980.1 → XP_030097840.1 retinol dehydrogenase 13 isoform X5

Conserved Domains (1) summary

cl21454
Location:1 → 207

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241976.1 → XP_030097836.1 retinol dehydrogenase 13 isoform X2

Conserved Domains (1) summary

cl21454
Location:18 → 293

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036152566.1 → XP_036008459.1 retinol dehydrogenase 13 isoform X4

Conserved Domains (1) summary

cl21454
Location:1 → 242

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036152565.1 → XP_036008458.1 retinol dehydrogenase 13 isoform X2

Conserved Domains (1) summary

cl21454
Location:18 → 293

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_030241977.1 → XP_030097837.1 retinol dehydrogenase 13 isoform X3

Conserved Domains (1) summary

cl21454
Location:18 → 258

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins