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    Timm17a translocase of inner mitochondrial membrane 17a [ Mus musculus (house mouse) ]

    Gene ID: 21854, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Timm17aprovided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 17aprovided by MGI
    Primary source
    MGI:MGI:1343131
    See related
    Ensembl:ENSMUSG00000062580 AllianceGenome:MGI:1343131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tim17a; mTim17a
    Summary
    Predicted to enable enzyme binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in positive regulation of protein processing and protein import into mitochondrial matrix. Located in mitochondrion. Is expressed in 4-cell stage embryo. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 42.4), placenta adult (RPKM 34.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Timm17a in Genome Data Viewer
    Location:
    1 E4; 1 58.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135229273..135241475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135301535..135313737, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase (aminopeptidase B) Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137210226-137210413 Neighboring gene predicted gene, 41956 Neighboring gene leiomodin 1 (smooth muscle) Neighboring gene STARR-seq mESC enhancer starr_02362 Neighboring gene STARR-seq mESC enhancer starr_02364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Ishihara N, et al. Nat Cell Biol, 2009 Aug. PMID 19578372
    2. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim17-A
    Names
    inner membrane preprotein translocase Tim17a
    translocator of inner mitochondrial membrane 17 kDa, a
    translocator of inner mitochondrial membrane 17a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360857.1 → NP_001347786.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC130277
      Conserved Domains (1) summary
      cl02381
      Location:1 → 149
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_001360858.1 → NP_001347787.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC130277
      Conserved Domains (1) summary
      cl02381
      Location:1 → 92
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    3. NM_011590.2 → NP_035720.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 2

      See identical proteins and their annotated locations for NP_035720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK003129
      Consensus CDS
      CCDS15318.1
      UniProtKB/Swiss-Prot
      Q9Z0V8
      UniProtKB/TrEMBL
      Q545U2
      Related
      ENSMUSP00000079883.4, ENSMUST00000081104.10
      Conserved Domains (1) summary
      TIGR00980
      Location:1 → 171
      3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135229273..135241475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001360856.1: Suppressed sequence

      Description
      NM_001360856.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0V8.1 GenPept UniProtKB/Swiss-Prot:Q9Z0V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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