Ak2 adenylate kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ak2provided by MGI
Official Full Name: adenylate kinase 2provided by MGI
Primary source: MGI:MGI:87978
See related: Ensembl:ENSMUSG00000028792 AllianceGenome:MGI:87978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ak-2; D4Ertd220e
Summary: Predicted to enable adenylate kinase activity. Predicted to contribute to nucleobase-containing compound kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and dATP metabolic process. Located in sperm mitochondrial sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 35.1), subcutaneous fat pad adult (RPKM 34.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 62.62 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (128887017..128905322)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (128993224..129011529)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
Title: The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.
Title: AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.
Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis.
Title: Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis.
Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
Title: Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
Title: The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth.
In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme.
Title: Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Title: Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha.
Title: Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.
Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified.
Title: Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.
AK2 in the flagellar accessory structures provides a mechanism to buffer the adenylate energy charge for sperm motility. Ak2 protein was localized to the mitochondrial sheath in the sperm midpiece.
Title: Adenylate kinases 1 and 2 are part of the accessory structures in the mouse sperm flagellum.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ak2 (e-PCR), detects polymorphism
- UniSTS:141059

RH126473 (e-PCR)
- UniSTS:163181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
contributes_to nucleobase-containing compound kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ADP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate kinase 2, mitochondrial

Names: AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; adenylate monophosphate kinase

NP_001029138.1

EC 2.7.4.3

NP_058591.2

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033966.4 → NP_001029138.1 adenylate kinase 2, mitochondrial isoform a

See identical proteins and their annotated locations for NP_001029138.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AL607086

Consensus CDS

CCDS18680.1

UniProtKB/Swiss-Prot

A2A820, Q3THT3, Q3TI11, Q3TKI6, Q8C7I9, Q9CY37, Q9WTP6

Related

ENSMUSP00000030583.7, ENSMUST00000030583.13

Conserved Domains (2) summary

cd01428
Location:17 → 219

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

pfam00406
Location:20 → 204

ADK; Adenylate kinase
NM_016895.4 → NP_058591.2 adenylate kinase 2, mitochondrial isoform b

See identical proteins and their annotated locations for NP_058591.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which has a shorter C-terminus, compared to isoform a.

Source sequence(s)

AL607086

Consensus CDS

CCDS18679.1

UniProtKB/Swiss-Prot

Q9WTP6

Related

ENSMUSP00000099664.5, ENSMUST00000102604.11

Conserved Domains (2) summary

cd01428
Location:17 → 219

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

pfam00406
Location:20 → 204

ADK; Adenylate kinase

RNA

NR_138540.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL607086, BM937796