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    Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20887, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sult1a1provided by MGI
    Official Full Name
    sulfotransferase family 1A, phenol-preferring, member 1provided by MGI
    Primary source
    MGI:MGI:102896
    See related
    Ensembl:ENSMUSG00000030711 AllianceGenome:MGI:102896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PST; Stp; Stp1; ST1A1; ST1A4; mSTp1
    Summary
    Enables nucleotide binding activity and sulfotransferase activity. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland and nervous system. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 40.1), liver E18 (RPKM 24.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sult1a1 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126272042..126289615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126672865..126690443, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1 Neighboring gene SAGA complex associated factor 29 Neighboring gene STARR-seq mESC enhancer starr_20153 Neighboring gene STARR-positive B cell enhancer ABC_E6601 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3751 Neighboring gene STARR-positive B cell enhancer ABC_E2252 Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133845996-133846179 Neighboring gene STARR-positive B cell enhancer ABC_E10475 Neighboring gene bolA family member 2 Neighboring gene coronin, actin binding protein 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders. Pagan C, et al. Transl Psychiatry, 2021 Jan 7. PMID 33414449, Free PMC Article
    2. Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2. Herrmann K, et al. Carcinogenesis, 2014 Apr. PMID 24318996
    3. Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver. Kong AN, et al. Biochim Biophys Acta, 1993 Jan 23. PMID 8424956
    4. Steroid sulfotransferases. Luu-The V, et al. J Endocrinol, 1996 Sep. PMID 8943792
    5. The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models. Sachse B, et al. Carcinogenesis, 2014 Oct. PMID 25053625

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts.
      Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
    2. SULT1A1 is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.
      Title: Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aryl sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavonol 3-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 4-nitrophenol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in catecholamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1A1
    Names
    aryl sulfotransferase
    arylsulfotransferase ST1A4
    phenol sulfotransferase
    phenol/aryl sulfotransferase
    sulfokinase
    sulfotransferase, phenol preferring 1
    NP_001390060.1
    NP_598431.2
    XP_006507601.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403131.1 → NP_001390060.1  sulfotransferase 1A1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124505

    2. NM_133670.3 → NP_598431.2  sulfotransferase 1A1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS40128.2
      UniProtKB/TrEMBL
      E9QNL5, Q9R1S5
      Related
      ENSMUSP00000101981.3, ENSMUST00000106373.9
      Conserved Domains (1) summary
      pfam00685
      Location:41 → 291
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126272042..126289615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507538.5 → XP_006507601.1  sulfotransferase 1A1 isoform X1

      See identical proteins and their annotated locations for XP_006507601.1

      UniProtKB/TrEMBL
      E9QNL5, Q9R1S5
      Conserved Domains (1) summary
      pfam00685
      Location:41 → 291
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52840.1 GenPept UniProtKB/Swiss-Prot:P52840

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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