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    Adam34 a disintegrin and metallopeptidase domain 34 [ Mus musculus (house mouse) ]

    Gene ID: 252866, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adam34provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 34provided by MGI
    Primary source
    MGI:MGI:2181992
    See related
    Ensembl:ENSMUSG00000079058 AllianceGenome:MGI:2181992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is expressed in seminiferous tubule and testis. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 4.6) See more
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    Genomic context

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    See Adam34 in Genome Data Viewer
    Location:
    8 A4; 8 24.07 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (44103346..44118597, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43650309..43665560, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 26A Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene Neighboring gene a disintegrin and metallopeptidase domain 34 like Neighboring gene predicted gene 5347 Neighboring gene predicted gene 45488 Neighboring gene STARR-seq mESC enhancer starr_21337 Neighboring gene WW domain binding protein 11 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family. Brachvogel B, et al. Gene, 2002 Apr 17. PMID 12034510
    2. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article
    3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metallopeptidase domain 34
    Names
    testase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145745.3 → NP_665688.2  a disintegrin and metallopeptidase domain 34

      See identical proteins and their annotated locations for NP_665688.2

      Status: VALIDATED

      Source sequence(s)
      AC131115, BC141203
      Consensus CDS
      CCDS22271.1
      UniProtKB/TrEMBL
      A2RSG8, Q8K4K0
      Related
      ENSMUSP00000148332.2, ENSMUST00000212185.2
      Conserved Domains (4) summary
      smart00608
      Location:492 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:207 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:416 → 488
      Disintegrin
      pfam01562
      Location:41 → 159
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      44103346..44118597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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