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Mtor mechanistic target of rapamycin kinase [ Mus musculus (house mouse) ]

Gene ID: 56717, updated on 27-Nov-2024

Summary

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Official Symbol: Mtorprovided by MGI
Official Full Name: mechanistic target of rapamycin kinaseprovided by MGI
Primary source: MGI:MGI:1928394
See related: Ensembl:ENSMUSG00000028991 AllianceGenome:MGI:1928394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik
Summary: Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in several structures, including central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 23.0), kidney adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Mtor in Genome Data Viewer

Location:: 4 E2; 4 78.76 cM

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148533039..148642142)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148448582..148557685)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.
Title: Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage.
Title: A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage.
The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.
Title: The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.
Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Title: Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.
Title: Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.
mTOR aggravated CD4[+] T cell pyroptosis by regulating the PPARgamma-Nrf2 pathway in sepsis.
Title: mTOR aggravated CD4(+) T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis.
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Title: ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
Title: Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
The role of autophagy regulated by the PI3K/AKT/mTOR pathway and innate lymphoid cells in eosinophilic chronic sinusitis with nasal polyps.
Title: The role of autophagy regulated by the PI3K/AKT/mTOR pathway and innate lymphoid cells in eosinophilic chronic sinusitis with nasal polyps.
PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis.
Title: PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis.

Submit: New GeneRIF Correction See all GeneRIFs (1060)

Phenotypes

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Associated conditions

Description	Tests
flat-top GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5) 1 citation
Gene trapped (1) 1 citation
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mtor (e-PCR), detects polymorphism
- UniSTS:527429

PMC299869P1 (e-PCR)
- UniSTS:272468

RH134710 (e-PCR)
- UniSTS:217988

MARC_7131-7132:996687522:1 (e-PCR)
- UniSTS:269711

MARC_17911-17912:1025019877:1 (e-PCR)
- UniSTS:268439

AI327068 (e-PCR)
- UniSTS:179103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables TFIIIC-class transcription factor complex binding	IEA Inferred from Electronic Annotation more info
enables TFIIIC-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in T-helper 1 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within TORC1 signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within TORC2 signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to pain	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to L-leucine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to methionine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to methionine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to osmotic stress	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within energy reserve metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell size	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of cholangiocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of iodide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleus localization	IEA Inferred from Electronic Annotation more info
involved_in nucleus localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of granulosa cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of myotube differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pentose-phosphate shunt	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of skeletal muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing, spreading of epidermal cells	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of protein destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of carbohydrate utilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to food	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation at synapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amino acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ruffle organization	IDA Inferred from Direct Assay more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within voluntary musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with PML body	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase mTOR

Names: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP12-rapamycin complex-associated protein; angiopoietin-like factor CDT6; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin target protein 1

NP_064393.2

EC 2.7.11.1

XP_006539140.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020009.2 → NP_064393.2 serine/threonine-protein kinase mTOR

See identical proteins and their annotated locations for NP_064393.2

Status: VALIDATED

Source sequence(s)

BC112904, CJ130100

Consensus CDS

CCDS18937.1

UniProtKB/Swiss-Prot

Q2KHT0, Q811J5, Q9CST1, Q9JLN9

Related

ENSMUSP00000099510.4, ENSMUST00000103221.10

Conserved Domains (6) summary

COG5032
Location:363 → 2549

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd05169
Location:2153 → 2431

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2518 → 2549

FATC; FATC domain

pfam08771
Location:2015 → 2112

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:854 → 1024

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:655 → 681

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

148533039..148642142

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539077.3 → XP_006539140.1 serine/threonine-protein kinase mTOR isoform X1

Conserved Domains (2) summary

COG5032
Location:2 → 1829

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

sd00044
Location:235 → 261

HEAT; HEAT repeat [structural motif]