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    Rbm45 RNA binding motif protein 45 [ Mus musculus (house mouse) ]

    Gene ID: 241490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm45provided by MGI
    Official Full Name
    RNA binding motif protein 45provided by MGI
    Primary source
    MGI:MGI:2387367
    See related
    Ensembl:ENSMUSG00000042369 AllianceGenome:MGI:2387367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drb1; Drbp1; G430095G15Rik
    Summary
    Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Is expressed in central nervous system and sensory organ. Orthologous to human RBM45 (RNA binding motif protein 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.8), CNS E14 (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm45 in Genome Data Viewer
    Location:
    2 C3; 2 44.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76200304..76214112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76369959..76383768)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene predicted gene, 52518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:75954028-75954329 Neighboring gene STARR-seq mESC enhancer starr_04889 Neighboring gene STARR-seq mESC enhancer starr_04890 Neighboring gene STARR-seq mESC enhancer starr_04891 Neighboring gene cytochrome c, testis Neighboring gene STARR-seq mESC enhancer starr_04893 Neighboring gene oxysterol binding protein-like 6 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of the Ets2 transcription factor in the proliferation, maturation, and survival of mouse thymocytes. Zaldumbide A, et al. J Immunol, 2002 Nov 1. PMID 12391198
    2. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. Tamada H, et al. Biochem Biophys Res Commun, 2002 Sep 13. PMID 12220514
    3. Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. Pyo JO, et al. J Biol Chem, 2008 Nov 7. PMID 18782777, Free PMC Article
    4. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4. Wang C, et al. Oncogene, 2024 Jan. PMID 38040804
    5. Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Jacobs FM, et al. Development, 2009 Jul. PMID 19515692, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
      Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    2. ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH
      Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 45
    Names
    RB-1
    developmentally regulated RNA binding protein 1
    dopamine receptor binding 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153405.2 → NP_700454.1  RNA-binding protein 45

      See identical proteins and their annotated locations for NP_700454.1

      Status: VALIDATED

      Source sequence(s)
      AK080420, AK140861, BB832413, CB597326
      Consensus CDS
      CCDS16157.1
      UniProtKB/Swiss-Prot
      Q8BHN5, Q8C1Z5
      UniProtKB/TrEMBL
      Q3US38
      Related
      ENSMUSP00000040420.5, ENSMUST00000046389.5
      Conserved Domains (4) summary
      cd12366
      Location:23 → 104
      RRM1_RBM45; RNA recognition motif 1 in RNA-binding protein 45 (RBM45) and similar proteins
      cd12367
      Location:120 → 193
      RRM2_RBM45; RNA recognition motif 2 in RNA-binding protein 45 (RBM45) and similar proteins
      cd12368
      Location:248 → 320
      RRM3_RBM45; RNA recognition motif 3 in RNA-binding protein 45 (RBM45) and similar proteins
      cd12369
      Location:393 → 460
      RRM4_RBM45; RNA recognition motif 4 in RNA-binding protein 45 (RBM45) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76200304..76214112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952822.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178090.2: Suppressed sequence

      Description
      NM_178090.2: This RefSeq was permanently suppressed because it contains a single nucleotide frameshift mutation that truncates the C-terminus of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay (
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHN5.1 GenPept UniProtKB/Swiss-Prot:Q8BHN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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