Adam28 a disintegrin and metallopeptidase domain 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam28provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 28provided by MGI
Primary source: MGI:MGI:105988
See related: Ensembl:ENSMUSG00000014725 AllianceGenome:MGI:105988
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDCL; Dtgn1; MDC-L; eMDCII; TECADAM; C130072N01Rik; D430033C21Rik
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]
Expression: Restricted expression toward genital fat pad adult (RPKM 58.0) See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 35.69 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (68842447..68893338, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (68604998..68655889, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
Title: Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage.
Title: CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.
The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1).
Title: The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adam28 (e-PCR), detects polymorphism
- UniSTS:474721

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables immunoglobulin receptor binding	IEA Inferred from Electronic Annotation more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 28

Names: ADAM 28; a disintegrin and metalloprotease domain 28; a disintegrin and metalloproteinase domain 28; disintegrin 1; metalloproteinase-disintegrin domain containing protein TECADAM; thymic epithelial cell-ADAM

NP_001041640.1

EC 3.4.24.-

NP_034212.1

EC 3.4.24.-

NP_899222.1

EC 3.4.24.-

XP_006518577.1

EC 3.4.24.-

XP_017171325.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048175.2 → NP_001041640.1 disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor

See identical proteins and their annotated locations for NP_001041640.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1. It is not known whether this isoform (4) is proteolytically processed in the same manner as isoform 1.

Source sequence(s)

AK078982, AK136715, BB629805, CT025563

Consensus CDS

CCDS36964.1

UniProtKB/TrEMBL

Q71U12

Related

ENSMUSP00000106701.2, ENSMUST00000111072.8

Conserved Domains (5) summary

smart00608
Location:496 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:206 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin; Disintegrin

pfam01421
Location:206 → 402

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:42 → 156

Pep_M12B_propep; Reprolysin family propeptide
NM_010082.2 → NP_034212.1 disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_034212.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK136715, BB629805, CT025563

Consensus CDS

CCDS36965.1

UniProtKB/Swiss-Prot

Q5D070, Q8K5D2, Q8K5D3, Q9JLN6

UniProtKB/TrEMBL

Q71U12

Related

ENSMUSP00000022642.6, ENSMUST00000022642.6

Conserved Domains (5) summary

smart00608
Location:496 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:206 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin; Disintegrin

pfam01421
Location:206 → 402

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:42 → 156

Pep_M12B_propep; Reprolysin family propeptide
NM_183366.3 → NP_899222.1 disintegrin and metalloproteinase domain-containing protein 28 isoform 2 precursor

See identical proteins and their annotated locations for NP_899222.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.

Source sequence(s)

AK136715, BB629805, CT025563

Consensus CDS

CCDS88698.1

UniProtKB/TrEMBL

Q71U12

Related

ENSMUSP00000153354.2, ENSMUST00000224039.2

Conserved Domains (5) summary

smart00608
Location:496 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:206 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin; Disintegrin

pfam01421
Location:206 → 402

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:42 → 156

Pep_M12B_propep; Reprolysin family propeptide

RNA

NR_102399.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK078982, AK136715, BB629805, CT025563

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

68842447..68893338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518514.4 → XP_006518577.1 disintegrin and metalloproteinase domain-containing protein 28 isoform X1

UniProtKB/TrEMBL

Q71U12

Conserved Domains (4) summary

smart00608
Location:496 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:206 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin

pfam01562
Location:31 → 158

Pep_M12B_propep; Reprolysin family propeptide
XM_017315836.2 → XP_017171325.1 disintegrin and metalloproteinase domain-containing protein 28 isoform X1

UniProtKB/TrEMBL

Q71U12

Conserved Domains (4) summary

smart00608
Location:496 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:206 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin

pfam01562
Location:31 → 158

Pep_M12B_propep; Reprolysin family propeptide

RNA

XR_001781095.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_176991.1: Suppressed sequence

Description

NM_176991.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.