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    Hdlbp high density lipoprotein (HDL) binding protein [ Mus musculus (house mouse) ]

    Gene ID: 110611, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hdlbpprovided by MGI
    Official Full Name
    high density lipoprotein (HDL) binding proteinprovided by MGI
    Primary source
    MGI:MGI:99256
    See related
    Ensembl:ENSMUSG00000034088 AllianceGenome:MGI:99256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd101e; 1110005P14Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in cholesterol metabolic process and lipid transport. Predicted to be located in cytoplasm and nucleus. Predicted to be part of high-density lipoprotein particle. Is expressed in brain; genitourinary system; and retina. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 70.8), limb E14.5 (RPKM 50.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdlbp in Genome Data Viewer
    Location:
    1 D; 1 47.24 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93333662..93406639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93405940..93478917, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene predicted gene, 26446 Neighboring gene anoctamin 7 Neighboring gene predicted gene, 17415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95362466-95362649 Neighboring gene STARR-positive B cell enhancer ABC_E1556 Neighboring gene STARR-positive B cell enhancer ABC_E4336 Neighboring gene septin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4337 Neighboring gene STARR-positive B cell enhancer ABC_E1223 Neighboring gene STARR-seq mESC enhancer starr_01729 Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene predicted gene, 41920 Neighboring gene STARR-seq mESC enhancer starr_01730 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins. Zinnall U, et al. Nat Commun, 2022 May 18. PMID 35585045, Free PMC Article
    2. Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5' leader sequence. Rohwedel J, et al. Cell Mol Life Sci, 2003 Aug. PMID 14504658, Free PMC Article
    3. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. Meiner VL, et al. J Biol Chem, 1998 Jan 9. PMID 9422770
    4. Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Begg DP, et al. Diabetes, 2014 Nov. PMID 24898144, Free PMC Article
    5. Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1. LeBoeuf RC, et al. Genomics, 1994 Sep 1. PMID 7829095

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
      Title: HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vigilin
    Names
    HDL-binding protein
    high density lipoprotein-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301364.2 → NP_001288293.1  vigilin isoform 1

      See identical proteins and their annotated locations for NP_001288293.1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      Consensus CDS
      CCDS15189.1
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7, Q3V1M8
      Related
      ENSMUSP00000043047.8, ENSMUST00000042498.14
      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I

    2. NM_001357556.2 → NP_001344485.1  vigilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      Consensus CDS
      CCDS15189.1
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7, Q3V1M8
      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I

    3. NM_001432849.1 → NP_001419778.1  vigilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7

    4. NM_001432850.1 → NP_001419779.1  vigilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7

    5. NM_001432851.1 → NP_001419780.1  vigilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7

    6. NM_001432852.1 → NP_001419781.1  vigilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108412

    7. NM_001432853.1 → NP_001419782.1  vigilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108412

    8. NM_001432854.1 → NP_001419783.1  vigilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108412

    9. NM_001432855.1 → NP_001419784.1  vigilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108412

    10. NM_001432856.1 → NP_001419785.1  vigilin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108412

    11. NM_133808.6 → NP_598569.1  vigilin isoform 1

      See identical proteins and their annotated locations for NP_598569.1

      Status: VALIDATED

      Source sequence(s)
      AC108412
      Consensus CDS
      CCDS15189.1
      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7, Q3V1M8
      Related
      ENSMUSP00000127903.2, ENSMUST00000170883.8
      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93333662..93406639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242016.2 → XP_030097876.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      Q8VDJ3
      UniProtKB/TrEMBL
      Q3U4Z7, Q3V1M8
      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I

    2. XM_006529077.5 → XP_006529140.1  vigilin isoform X1

      Related
      ENSMUSP00000139671.2, ENSMUST00000186164.7
      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I

    3. XM_006529075.4 → XP_006529138.1  vigilin isoform X1

      Conserved Domains (1) summary
      cl00098
      Location:875 → 970
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDJ3.1 GenPept UniProtKB/Swiss-Prot:Q8VDJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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