Slc2a8 solute carrier family 2, (facilitated glucose transporter), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a8provided by MGI
Official Full Name: solute carrier family 2, (facilitated glucose transporter), member 8provided by MGI
Primary source: MGI:MGI:1860103
See related: Ensembl:ENSMUSG00000026791 AllianceGenome:MGI:1860103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLUT8; GlutX1; D2Ertd44e
Summary: Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose transmembrane transport; dehydroascorbic acid transport; and fructose transmembrane transport. Acts upstream of or within insulin receptor signaling pathway and response to hypoxia. Located in plasma membrane. Is expressed in several structures, including adipose tissue; gut; liver; placenta; and spleen. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 64.4), ovary adult (RPKM 28.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32862993..32872088, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32972981..32982083, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis.
Title: Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis.
Cell-specific expression of functional glucose transporter 8 in mammary gland.
Title: Cell-specific expression of functional glucose transporter 8 in mammary gland.
Adiponectin stimulates glucose uptake in mouse blastocysts and embryonic carcinoma cells.
Title: Adiponectin stimulates glucose uptake in mouse blastocysts and embryonic carcinoma cells.
trehalose and GLUT8 coordinately contribute to energy supply in the brain.
Title: Trehalose intake and exercise upregulate a glucose transporter, GLUT8, in the brain.
The spatial-temporal synchrony between expression of GLUT8/GLUT1 and alveolar cell proliferation, and its localization in cis-Golgi associated to lactose synthase complex, suggest that both transporters are involved in glucose uptake into this organelle, supporting lactose synthesis.
Title: GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells.
Data demonstrate that hepatocyte GLUT8 regulates adaptive fasting in part through regulation of the PPARalpha signaling cascade. Moreover, the ketotic and thermic responses to fasting are differentially encoded within the GLUT8-PPARalpha communication axis.
Title: Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice.
Insulin-stimulated translocation of GLUT4 and GLUT8 was down-regulated in the atria of insulin resistance animals, as well as their total protein expression.
Title: Dysregulation of insulin-sensitive glucose transporters during insulin resistance-induced atrial fibrillation.
these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction.
Title: SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.
Neonatal hypothyroridism downregulates the expressions of GLUT3 and GLUT8 in the testis of perpubertal mice.
Title: Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43.
The findings support the hypothesis of the transport of intravascularGLUT8 through the epithelial cells of the choroid plexus and the ependymal cells.
Title: Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Markers

D2Ertd44e (e-PCR), detects polymorphism
- UniSTS:167320

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose uniporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables galactose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fructose transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within galactose transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within glucose metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 8

Names: GLUT-8; glucose transporter X1; glucose transporter type 8; glucose transporter type X1; intestinal GLUT8 transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356409.2 → NP_001343338.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL731852

Consensus CDS

CCDS89475.1

UniProtKB/TrEMBL

Q2TK26, Q2TK27

Related

ENSMUSP00000141959.2, ENSMUST00000153484.7

Conserved Domains (1) summary

cl26863
Location:29 → 290

Sugar_tr; Sugar (and other) transporter
NM_001421583.1 → NP_001408512.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL731852
NM_001421584.1 → NP_001408513.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL731852
NM_001421585.1 → NP_001408514.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 5

Status: VALIDATED

Source sequence(s)

AL731852
NM_001421586.1 → NP_001408515.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 6

Status: VALIDATED

Source sequence(s)

AL731852
NM_001421587.1 → NP_001408516.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AL731852
NM_019488.6 → NP_062361.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_062361.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL731852

Consensus CDS

CCDS15937.1

UniProtKB/Swiss-Prot

Q5BKP8, Q9JIF3, Q9JJP4, Q9JJZ0

Related

ENSMUSP00000028129.8, ENSMUST00000028129.13

Conserved Domains (2) summary

cd06174
Location:31 → 459

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:29 → 474

Sugar_tr; Sugar (and other) transporter

RNA

NR_151460.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL731852
NR_151461.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks four alternate exons compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AL731852
NR_185315.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL731852
NR_185316.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL731852

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

32862993..32872088 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162406.1 → XP_036018299.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X1

UniProtKB/TrEMBL

Q8VDJ4

Conserved Domains (1) summary

cl28910
Location:1 → 275

MFS; Major Facilitator Superfamily
XM_036162405.1 → XP_036018298.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X1

UniProtKB/TrEMBL

Q8VDJ4

Conserved Domains (1) summary

cl28910
Location:1 → 275

MFS; Major Facilitator Superfamily