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    Ints2 integrator complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 70422, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ints2provided by MGI
    Official Full Name
    integrator complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1917672
    See related
    Ensembl:ENSMUSG00000018068 AllianceGenome:MGI:1917672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1287; 2810417D08Rik
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E14 (RPKM 7.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints2 in Genome Data Viewer
    Location:
    11 C; 11 51.71 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86101507..86148912, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86210681..86257609, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30261 Neighboring gene predicted gene, 20759 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene STARR-seq mESC enhancer starr_30264 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1425 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30265 Neighboring gene mediator complex subunit 13 Neighboring gene predicted gene, 57586 Neighboring gene STARR-positive B cell enhancer ABC_E10702 Neighboring gene STARR-positive B cell enhancer ABC_E1837 Neighboring gene predicted gene, 38937

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of the human Integrator complex
      Title: Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141509

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 2
    Names
    int2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363129.1 → NP_001350058.1  integrator complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL592065
      Consensus CDS
      CCDS25198.1
      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    2. NM_001363130.1 → NP_001350059.1  integrator complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL592065, KY499705
      UniProtKB/TrEMBL
      A0A1S6GWJ5, Q148R8
      Related
      ENSMUSP00000103674.2, ENSMUST00000108039.8
      Conserved Domains (1) summary
      pfam14750
      Location:44 → 1151
      INTS2; Integrator complex subunit 2

    3. NM_027421.3 → NP_081697.2  integrator complex subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_081697.2

      Status: VALIDATED

      Source sequence(s)
      AK129323, AK164097, AL592065, BC059056, CF166557
      Consensus CDS
      CCDS25198.1
      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Related
      ENSMUSP00000018212.7, ENSMUST00000018212.13
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86101507..86148912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534179.5 → XP_006534242.1  integrator complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006534242.1

      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    2. XM_006534180.4 → XP_006534243.1  integrator complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006534243.1

      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    3. XM_030246300.2 → XP_030102160.1  integrator complex subunit 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    4. XM_006534176.4 → XP_006534239.1  integrator complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006534239.1

      UniProtKB/TrEMBL
      A0A1S6GWJ5, Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:44 → 1151
      INTS2; Integrator complex subunit 2

    5. XM_006534178.5 → XP_006534241.1  integrator complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:34 → 1141
      INTS2; Integrator complex subunit 2

    6. XM_006534181.5 → XP_006534244.1  integrator complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006534244.1

      UniProtKB/Swiss-Prot
      Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
      UniProtKB/TrEMBL
      Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:24 → 1131
      INTS2; Integrator complex subunit 2

    7. XM_006534177.5 → XP_006534240.1  integrator complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006534240.1

      UniProtKB/TrEMBL
      A0A1S6GWJ5, Q148R8
      Conserved Domains (1) summary
      pfam14750
      Location:44 → 1151
      INTS2; Integrator complex subunit 2

    RNA

    1. XR_879737.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UK8.2 GenPept UniProtKB/Swiss-Prot:Q80UK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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