Gpx5 glutathione peroxidase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpx5provided by MGI
Official Full Name: glutathione peroxidase 5provided by MGI
Primary source: MGI:MGI:104886
See related: Ensembl:ENSMUSG00000004344 AllianceGenome:MGI:104886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arep
Summary: Predicted to enable glutathione peroxidase activity. Acts upstream of or within cellular response to oxidative stress. Located in extracellular space and sperm plasma membrane. Is expressed in several structures, including male reproductive gland or organ and placenta. Orthologous to human GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 3445.3) See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 7.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (21470599..21476897, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (21286429..21292727, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring novel function of Gpx5 antioxidant activity: Assisting epididymal cells secrete functional extracellular vesicles.
Title: Exploring novel function of Gpx5 antioxidant activity: Assisting epididymal cells secrete functional extracellular vesicles.
Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Title: Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice
Title: Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
GPX5 is a potent antioxidant scavenger in the luminal compartment of the mouse cauda epididymidis that protects spermatozoa from oxidative injuries.
Title: Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice.
results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species
Title: Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.
GPX5 gene is expressed in a temporally regulated manner during mouse embryonic development.
Title: GPX5, the selenium-independent glutathione peroxidase-encoding single copy gene is differentially expressed in mouse epididymis.
GPX5 is found in the caput & cauda epididymis lumen in 3 locations: as a soluble protein in the caput epididymal fluid, weakly bound to caput sperm membranes, or associated to lipid-containing structures causing a protective effect against proteolysis.
Title: GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV379049 (e-PCR)
- UniSTS:180501

D0M13Mit17 (e-PCR)
- UniSTS:116537

D13Mit17 (e-PCR), detects polymorphism
- UniSTS:116537

NoName (e-PCR)
- UniSTS:489133

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525489

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525490

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525491

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525492

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525493

Gpx5 (e-PCR), detects polymorphism
- UniSTS:525494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in sperm plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epididymal secretory glutathione peroxidase

Names: EGLP; GPx-5; GSHPx-5; arMEP24; epididymis-specific glutathione peroxidase-like protein; lysosomal trafficking regulator, long splice form; major androgen-regulated protein

NP_034473.2

EC 1.11.1.9

XP_011242585.1

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010343.2 → NP_034473.2 epididymal secretory glutathione peroxidase precursor

See identical proteins and their annotated locations for NP_034473.2

Status: VALIDATED

Source sequence(s)

AK029731, AK033841, BC105648

Consensus CDS

CCDS26270.1

UniProtKB/Swiss-Prot

E9QK84, P21765

UniProtKB/TrEMBL

Q496Q2, Q8CDQ5

Related

ENSMUSP00000106117.3, ENSMUST00000110491.9

Conserved Domains (1) summary

cd00340
Location:39 → 211

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

21470599..21476897 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244283.3 → XP_011242585.1 epididymal secretory glutathione peroxidase isoform X1

Conserved Domains (1) summary

cl00388
Location:56 → 98

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold