Sybu syntabulin (syntaxin-interacting) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sybuprovided by MGI
Official Full Name: syntabulin (syntaxin-interacting)provided by MGI
Primary source: MGI:MGI:2442392
See related: Ensembl:ENSMUSG00000022340 AllianceGenome:MGI:2442392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Golsyn
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including axonal transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic activity. Predicted to act upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in several cellular components, including dense body; microtubule; and vesicle. Predicted to be active in cytoplasmic microtubule. Is expressed in alimentary system; central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 12.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.2; 15 16.91 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (44535252..44651466, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (44671856..44788070, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion
Title: The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.
results may indicate a significant role for this protein in neuronal cells and other types of cells such as those of the choroid plexus and ciliary body
Title: Expression of m-Golsyn/Syntabulin gene during mouse brain development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde neuronal dense core vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in anterograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in axonal transport of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of synaptic activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic activity	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse maturation	IEA Inferred from Electronic Annotation more info
involved_in synapse maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in dense body	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
colocalizes_with vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntabulin

Names: Golgi-localized syntaphilin-related protein; Golsyn/Syntabulin; syntaxin-1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032727.2 → NP_001027899.1 syntabulin isoform b

See identical proteins and their annotated locations for NP_001027899.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks two consecutive in-frame exons in the central coding region, compared to variant a. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AC100730

Consensus CDS

CCDS37070.1

UniProtKB/Swiss-Prot

Q8BHS8

Related

ENSMUSP00000105898.2, ENSMUST00000110269.8

Conserved Domains (1) summary

pfam15290
Location:167 → 357

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001285840.1 → NP_001272769.1 syntabulin isoform c

See identical proteins and their annotated locations for NP_001272769.1

Status: VALIDATED

Description

Transcript Variant: This variant (d) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant a. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.

Source sequence(s)

AB232447, AK220268

Consensus CDS

CCDS37071.1

UniProtKB/Swiss-Prot

Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BHS8, Q8BI27

Related

ENSMUSP00000153759.2, ENSMUST00000228057.2

Conserved Domains (1) summary

pfam15290
Location:239 → 429

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001285841.1 → NP_001272770.1 syntabulin isoform d

See identical proteins and their annotated locations for NP_001272770.1

Status: VALIDATED

Description

Transcript Variant: This variant (e) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at a downstream start codon. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.

Source sequence(s)

AB232447, AC100730, CO425611

UniProtKB/Swiss-Prot

Q8BHS8

Conserved Domains (1) summary

pfam15290
Location:5 → 300

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001285842.1 → NP_001272771.1 syntabulin isoform d

See identical proteins and their annotated locations for NP_001272771.1

Status: VALIDATED

Description

Transcript Variant: This variant (f) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at a downstream start codon. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.

Source sequence(s)

AB232447, AC100730, CF724604

UniProtKB/Swiss-Prot

Q8BHS8

Conserved Domains (1) summary

pfam15290
Location:5 → 300

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001285843.1 → NP_001272772.1 syntabulin isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (g) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a.

Source sequence(s)

AB232447, AC100730, BY299369

UniProtKB/Swiss-Prot

Q8BHS8

Conserved Domains (1) summary

pfam15290
Location:138 → 328

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001285844.1 → NP_001272773.1 syntabulin isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (h) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (f) has a distinct and shorter N-terminus, compared to isoform a.

Source sequence(s)

AB232447, AC100730, CO425611, CX224257

UniProtKB/Swiss-Prot

Q8BHS8

Conserved Domains (1) summary

pfam15290
Location:102 → 292

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001358582.2 → NP_001345511.1 syntabulin isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (i) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (g) has a distinct and shorter N-terminus, compared to isoform a.

Source sequence(s)

AC100730

Consensus CDS

CCDS88763.1

Related

ENSMUSP00000154372.2, ENSMUST00000227305.2

Conserved Domains (1) summary

pfam15290
Location:238 → 428

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001358583.1 → NP_001345512.1 syntabulin isoform h

Status: VALIDATED

Description

Transcript Variant: This variant (j) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (h) has a distinct and shorter N-terminus, compared to isoform a.

Source sequence(s)

AC100730

Related

ENSMUST00000226825.2

Conserved Domains (1) summary

pfam15290
Location:93 → 374

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001358584.1 → NP_001345513.1 syntabulin isoform h

Status: VALIDATED

Description

Transcript Variant: This variant (k) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (i) has a distinct and shorter N-terminus, compared to isoform a.

Source sequence(s)

AC100730

Conserved Domains (1) summary

pfam15290
Location:93 → 374

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_001416535.1 → NP_001403464.1 syntabulin isoform i

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416536.1 → NP_001403465.1 syntabulin isoform j

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416537.1 → NP_001403466.1 syntabulin isoform k

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416538.1 → NP_001403467.1 syntabulin isoform l

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416539.1 → NP_001403468.1 syntabulin isoform m

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416540.1 → NP_001403469.1 syntabulin isoform n

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416541.1 → NP_001403470.1 syntabulin isoform o

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416542.1 → NP_001403471.1 syntabulin isoform h

Status: VALIDATED

Source sequence(s)

AC100730
NM_001416543.1 → NP_001403472.1 syntabulin isoform d

Status: VALIDATED

Source sequence(s)

AC100730
NM_176998.5 → NP_795972.2 syntabulin isoform a

See identical proteins and their annotated locations for NP_795972.2

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC100730

Consensus CDS

CCDS37069.1

UniProtKB/Swiss-Prot

Q8BHS8

Related

ENSMUSP00000087511.5, ENSMUST00000090057.6

Conserved Domains (1) summary

pfam15290
Location:367 → 557

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
NM_178765.4 → NP_848880.2 syntabulin isoform c

See identical proteins and their annotated locations for NP_848880.2

Status: VALIDATED

Description

Transcript Variant: This variant (c) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant a. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.

Source sequence(s)

AC100730

Consensus CDS

CCDS37071.1

UniProtKB/Swiss-Prot

Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BHS8, Q8BI27

Related

ENSMUSP00000105896.2, ENSMUST00000110267.9

Conserved Domains (1) summary

pfam15290
Location:239 → 429

Syntaphilin; Golgi-localized syntaxin-1-binding clamp

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

44535252..44651466 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521067.4 → XP_006521130.3 syntabulin isoform X2

Conserved Domains (1) summary

pfam15290
Location:350 → 631

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_017316662.2 → XP_017172151.1 syntabulin isoform X1

Conserved Domains (1) summary

pfam15290
Location:351 → 632

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_017316665.1 → XP_017172154.1 syntabulin isoform X9

Conserved Domains (1) summary

pfam15290
Location:151 → 432

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159461.1 → XP_036015354.1 syntabulin isoform X8

Conserved Domains (1) summary

pfam15290
Location:173 → 468

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_017316664.1 → XP_017172153.1 syntabulin isoform X7

Conserved Domains (1) summary

pfam15290
Location:181 → 462

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159463.1 → XP_036015356.1 syntabulin isoform X12

Conserved Domains (1) summary

pfam15290
Location:5 → 300

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159460.1 → XP_036015353.1 syntabulin isoform X6

Conserved Domains (1) summary

pfam15290
Location:221 → 516

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159459.1 → XP_036015352.1 syntabulin isoform X5

Conserved Domains (1) summary

pfam15290
Location:222 → 517

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159458.1 → XP_036015351.1 syntabulin isoform X4

Conserved Domains (1) summary

pfam15290
Location:274 → 569

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159465.1 → XP_036015358.1 syntabulin isoform X12

Conserved Domains (1) summary

pfam15290
Location:5 → 300

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159462.1 → XP_036015355.1 syntabulin isoform X10

Conserved Domains (1) summary

pfam15290
Location:99 → 394

Syntaphilin; Golgi-localized syntaxin-1-binding clamp
XM_036159464.1 → XP_036015357.1 syntabulin isoform X12

Conserved Domains (1) summary

pfam15290
Location:5 → 300

Syntaphilin; Golgi-localized syntaxin-1-binding clamp