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    Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 [ Mus musculus (house mouse) ]

    Gene ID: 67838, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajb11provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B11provided by MGI
    Primary source
    MGI:MGI:1915088
    See related
    Ensembl:ENSMUSG00000004460 AllianceGenome:MGI:1915088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj9; ERdj3; ERj3p; ABBP-2; 1810031F23Rik
    Summary
    Enables signaling receptor binding activity and unfolded protein binding activity. Acts upstream of or within mRNA modification and negative regulation of neurogenesis. Located in cytoplasm; extracellular space; and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 25.6), liver E14 (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajb11 in Genome Data Viewer
    Location:
    16 B1; 16 13.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22676595..22698384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22857845..22879634)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30416 Neighboring gene crystallin, gamma S Neighboring gene TBCC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E484 Neighboring gene predicted gene, 30505 Neighboring gene alpha-2-HS-glycoprotein Neighboring gene predicted gene, 30611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. Yu M, et al. J Biol Chem, 2000 Aug 11. PMID 10827079
    2. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. Genereux JC, et al. EMBO J, 2015 Jan 2. PMID 25361606, Free PMC Article
    3. Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice. Ghosh Roy S, et al. J Am Soc Nephrol, 2023 Sep 1. PMID 37332102, Free PMC Article
    4. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Shen Y, et al. Mol Biol Cell, 2005 Jan. PMID 15525676, Free PMC Article
    5. Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. Marcinowski M, et al. Nat Struct Mol Biol, 2011 Feb. PMID 21217698

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neurogenesis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endoplasmic reticulum chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoplasmic reticulum chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein folding chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 11
    Names
    APOBEC1-binding protein 2
    DnaJ (Hsp40) homolog, subfamily B, member 11
    ER-associated Hsp40 co-chaperone
    ER-associated dnaJ protein 3
    ER-resident protein ERdj3
    endoplasmic reticulum DNA J domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190804.1 → NP_001177733.1  dnaJ homolog subfamily B member 11 precursor

      See identical proteins and their annotated locations for NP_001177733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK050500, BY270762, BY617271, BY640220
      Consensus CDS
      CCDS28070.1
      UniProtKB/Swiss-Prot
      A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
      Related
      ENSMUSP00000004574.8, ENSMUST00000004574.14
      Conserved Domains (1) summary
      COG0484
      Location:22 → 344
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_001190805.1 → NP_001177734.1  dnaJ homolog subfamily B member 11 precursor

      See identical proteins and their annotated locations for NP_001177734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK148511, BY270762, BY617271, BY625840, BY640220, CT027991
      Consensus CDS
      CCDS28070.1
      UniProtKB/Swiss-Prot
      A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
      Related
      ENSMUSP00000137542.2, ENSMUST00000178320.2
      Conserved Domains (1) summary
      COG0484
      Location:22 → 344
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    3. NM_026400.5 → NP_080676.3  dnaJ homolog subfamily B member 11 precursor

      See identical proteins and their annotated locations for NP_080676.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK148511, BY270762
      Consensus CDS
      CCDS28070.1
      UniProtKB/Swiss-Prot
      A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
      Related
      ENSMUSP00000126828.3, ENSMUST00000166487.10
      Conserved Domains (1) summary
      COG0484
      Location:22 → 344
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22676595..22698384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KV1.1 GenPept UniProtKB/Swiss-Prot:Q99KV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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