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    Greb1l growth regulation by estrogen in breast cancer-like [ Mus musculus (house mouse) ]

    Gene ID: 381157, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Greb1lprovided by MGI
    Official Full Name
    growth regulation by estrogen in breast cancer-likeprovided by MGI
    Primary source
    MGI:MGI:3576497
    See related
    Ensembl:ENSMUSG00000042942 AllianceGenome:MGI:3576497
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4095
    Summary
    Acts upstream of or within several processes, including kidney development; paramesonephric duct development; and reproductive structure development. Predicted to be located in membrane. Is expressed in several structures, including brain; liver; tail unsegmented mesenchyme; thymus; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 5.2), adrenal adult (RPKM 2.3) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Greb1l in Genome Data Viewer
    Location:
    18 A1; 18 5.0 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10324933..10562945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10324933..10562945)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_43791 Neighboring gene STARR-seq mESC enhancer starr_43793 Neighboring gene RAE1 RNA export 1 homolog pseudogene Neighboring gene nuclear transport factor 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_43798 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:10532920-10533103 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene small nuclear ribonucleoprotein D1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
    2. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. De Tomasi L, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100091, Free PMC Article
    3. Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells. Bernheim S, et al. Dev Cell, 2023 Nov 6. PMID 37852253
    4. Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Chal J, et al. Development, 2018 Mar 19. PMID 29555813
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.
      Title: Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA4095

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesonephric duct development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within paramesonephric duct development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within uterus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GREB1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083628.1 → NP_001077097.1  GREB1-like protein

      See identical proteins and their annotated locations for NP_001077097.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102441, AC124740, AEKQ02056206
      Consensus CDS
      CCDS37736.1
      UniProtKB/Swiss-Prot
      B9EJV3, Q5DTN6
      Related
      ENSMUSP00000049003.9, ENSMUST00000048977.16
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1913
      GREB1; Gene regulated by oestrogen in breast cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10324933..10562945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526068.4 → XP_006526131.1  GREB1-like protein isoform X1

      See identical proteins and their annotated locations for XP_006526131.1

      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1956
      GREB1; Gene regulated by oestrogen in breast cancer

    2. XM_006526069.3 → XP_006526132.1  GREB1-like protein isoform X3

      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1610
      GREB1; Gene regulated by oestrogen in breast cancer

    3. XM_011246970.4 → XP_011245272.1  GREB1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011245272.1

      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1956
      GREB1; Gene regulated by oestrogen in breast cancer

    4. XM_030250521.2 → XP_030106381.1  GREB1-like protein isoform X2

      UniProtKB/Swiss-Prot
      B9EJV3, Q5DTN6
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1913
      GREB1; Gene regulated by oestrogen in breast cancer

    5. XM_036161197.1 → XP_036017090.1  GREB1-like protein isoform X4

      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1011
      GREB1; Gene regulated by oestrogen in breast cancer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9EJV3.1 GenPept UniProtKB/Swiss-Prot:B9EJV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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