Tnfaip8 tumor necrosis factor, alpha-induced protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip8provided by MGI
Official Full Name: tumor necrosis factor, alpha-induced protein 8provided by MGI
Primary source: MGI:MGI:2147191
See related: Ensembl:ENSMUSG00000062210 AllianceGenome:MGI:2147191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nded; Tipe; Gg2-1; Ssc-2; Gm10539; E130304C20Rik
Summary: Enables molecular sequestering activity and small molecule binding activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; choroid plexus; musculoskeletal system; respiratory system; and thymus primordium. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 36.9), placenta adult (RPKM 10.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 27.18 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (50112494..50226296)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (49979427..50093229)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.
Title: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.
Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
Title: Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors.
Title: TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors.
TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT.
Title: TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT.
The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation.
Title: The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation.
TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation.
Title: TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation.
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling.
Title: TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling.
Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation.
Title: TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells.
TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice.
Title: Effect of tumor necrosis factor-α-induced protein 8 on the immune response of CD4+ T lymphocytes in mice following acute insult.
CD4+ T lymphocyte proliferative activity was significantly down-regulated when TNFAIP8 gene was silenced by siRNA in mice at 24 h post burn. Down-regulation of TNFAIP8 can significantly decrease expression levels of IL-2 and soluble IL-2R at 24 h after thermal injury.
Title: Effect of tumor necrosis factor-induced protein 8 on T-cell-mediated immunity in mice after thermal injury.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126874 (e-PCR)
- UniSTS:209381

NoName (e-PCR)
- UniSTS:237800

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables molecular sequestering activity	EXP Inferred from Experiment more info	PubMed
enables small molecule binding	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 8

Names: TNF alpha-induced protein 8; TNF-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177759.1 → NP_001171230.1 tumor necrosis factor alpha-induced protein 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC120859, AC166570

Consensus CDS

CCDS50288.1

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

UniProtKB/TrEMBL

D3YWJ5

Related

ENSMUSP00000120712.3, ENSMUST00000148989.3

Conserved Domains (1) summary

pfam05527
Location:7 → 185

DUF758; Domain of unknown function (DUF758)
NM_001177760.1 → NP_001171231.1 tumor necrosis factor alpha-induced protein 8 isoform 3

See identical proteins and their annotated locations for NP_001171231.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, and lacks an alternate segment, compared to variant 1. The resulting isoform (3z) has shorter and distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AC120859, AK163339, BB623947

Consensus CDS

CCDS50287.1

UniProtKB/Swiss-Prot

Q921Z5

Related

ENSMUSP00000136030.2, ENSMUST00000179937.2

Conserved Domains (1) summary

pfam05527
Location:7 → 109

DUF758; Domain of unknown function (DUF758)
NM_001360935.1 → NP_001347864.1 tumor necrosis factor alpha-induced protein 8 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC120859

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

Related

ENSMUSP00000136152.2, ENSMUST00000128377.2

Conserved Domains (1) summary

pfam05527
Location:11 → 189

DUF758; Domain of unknown function (DUF758)
NM_134131.2 → NP_598892.2 tumor necrosis factor alpha-induced protein 8 isoform 1

See identical proteins and their annotated locations for NP_598892.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC120859, AK149901, BY108131

Consensus CDS

CCDS37817.2

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

UniProtKB/TrEMBL

D3Z325

Related

ENSMUSP00000119041.3, ENSMUST00000148159.3

Conserved Domains (1) summary

pfam05527
Location:51 → 205

DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

50112494..50226296

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250259.1 → XP_030106119.1 tumor necrosis factor alpha-induced protein 8 isoform X3

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

Conserved Domains (1) summary

pfam05527
Location:1 → 163

DUF758; Domain of unknown function (DUF758)
XM_006525480.2 → XP_006525543.1 tumor necrosis factor alpha-induced protein 8 isoform X2

See identical proteins and their annotated locations for XP_006525543.1

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

Conserved Domains (1) summary

pfam05527
Location:10 → 188

DUF758; Domain of unknown function (DUF758)
XM_011246796.2 → XP_011245098.1 tumor necrosis factor alpha-induced protein 8 isoform X1

See identical proteins and their annotated locations for XP_011245098.1

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

UniProtKB/TrEMBL

D3Z325

Conserved Domains (1) summary

pfam05527
Location:51 → 205

DUF758; Domain of unknown function (DUF758)
XM_036160917.1 → XP_036016810.1 tumor necrosis factor alpha-induced protein 8 isoform X1

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

UniProtKB/TrEMBL

D3Z325

Conserved Domains (1) summary

pfam05527
Location:51 → 205

DUF758; Domain of unknown function (DUF758)
XM_030250258.1 → XP_030106118.1 tumor necrosis factor alpha-induced protein 8 isoform X3

UniProtKB/Swiss-Prot

Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5

Conserved Domains (1) summary

pfam05527
Location:1 → 163

DUF758; Domain of unknown function (DUF758)