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    Pak6 p21 (RAC1) activated kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 214230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pak6provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 6provided by MGI
    Primary source
    MGI:MGI:2679420
    See related
    Ensembl:ENSMUSG00000074923 AllianceGenome:MGI:2679420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732456M09
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; liver; retina; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK6 (p21 (RAC1) activated kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 13.2), CNS E18 (RPKM 12.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pak6 in Genome Data Viewer
    Location:
    2 E5; 2 59.41 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118493531..118528501)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118663045..118698020)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9527 Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8791 Neighboring gene BUB1B, mitotic checkpoint serine/threonine kinase Neighboring gene STARR-seq mESC enhancer starr_05463 Neighboring gene STARR-seq mESC enhancer starr_05464 Neighboring gene STARR-seq mESC enhancer starr_05465 Neighboring gene STARR-seq mESC enhancer starr_05466 Neighboring gene STARR-seq mESC enhancer starr_05467 Neighboring gene STARR-positive B cell enhancer ABC_E5965 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C, beta 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118554101-118554254

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Furnari MA, et al. Nutr Neurosci, 2014 Apr. PMID 23710594, Free PMC Article
    2. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. Furnari MA, et al. PLoS One, 2013. PMID 23593460, Free PMC Article
    3. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Nekrasova T, et al. Dev Biol, 2008 Oct 1. PMID 18675265
    4. Targeted disruption of the gene for the PAK5 kinase in mice. Li X, et al. Mol Cell Biol, 2003 Oct. PMID 14517284, Free PMC Article
    5. PAK2 is necessary for myelination in the peripheral nervous system. Hu B, et al. Brain, 2024 May 3. PMID 38079473, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease
      Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
    2. data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake
      Title: Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.
    3. functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
      Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
    4. Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
      Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 6
    Names
    PAK-6
    p21 protein (Cdc42/Rac)-activated kinase 6
    p21-activated kinase 6
    NP_001028426.2
    NP_001139326.1
    NP_001411690.1
    NP_001411691.1
    XP_011237721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033254.4 → NP_001028426.2  serine/threonine-protein kinase PAK 6

      See identical proteins and their annotated locations for NP_001028426.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants encode the same protein.
      Source sequence(s)
      AL845470
      Consensus CDS
      CCDS16580.1
      UniProtKB/Swiss-Prot
      Q3TY26, Q3ULB5
      UniProtKB/TrEMBL
      B2RWY1
      Related
      ENSMUSP00000097153.4, ENSMUST00000099557.10
      Conserved Domains (2) summary
      cd06659
      Location:386 → 682
      STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
      pfam00786
      Location:11 → 63
      PBD; P21-Rho-binding domain

    2. NM_001145854.2 → NP_001139326.1  serine/threonine-protein kinase PAK 6

      See identical proteins and their annotated locations for NP_001139326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL845470
      Consensus CDS
      CCDS16580.1
      UniProtKB/Swiss-Prot
      Q3TY26, Q3ULB5
      UniProtKB/TrEMBL
      B2RWY1
      Related
      ENSMUSP00000106477.2, ENSMUST00000110853.8
      Conserved Domains (2) summary
      cd06659
      Location:386 → 682
      STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
      pfam00786
      Location:11 → 63
      PBD; P21-Rho-binding domain

    3. NM_001424761.1 → NP_001411690.1  serine/threonine-protein kinase PAK 6

      Status: VALIDATED

      Source sequence(s)
      AL845470
      UniProtKB/Swiss-Prot
      Q3TY26, Q3ULB5
      UniProtKB/TrEMBL
      B2RWY1

    4. NM_001424762.1 → NP_001411691.1  serine/threonine-protein kinase PAK 6

      Status: VALIDATED

      Source sequence(s)
      AL845470
      UniProtKB/Swiss-Prot
      Q3TY26, Q3ULB5
      UniProtKB/TrEMBL
      B2RWY1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118493531..118528501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239419.1 → XP_011237721.1  serine/threonine-protein kinase PAK 6 isoform X1

      See identical proteins and their annotated locations for XP_011237721.1

      UniProtKB/Swiss-Prot
      Q3TY26, Q3ULB5
      UniProtKB/TrEMBL
      B2RWY1
      Conserved Domains (2) summary
      cd06659
      Location:386 → 682
      STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
      pfam00786
      Location:11 → 63
      PBD; P21-Rho-binding domain

    RNA

    1. XR_866265.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ULB5.1 GenPept UniProtKB/Swiss-Prot:Q3ULB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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