Ssx2ip SSX family member 2 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ssx2ipprovided by MGI
Official Full Name: SSX family member 2 interacting proteinprovided by MGI
Primary source: MGI:MGI:2139150
See related: Ensembl:ENSMUSG00000036825 AllianceGenome:MGI:2139150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adip
Summary: Predicted to enable protein domain specific binding activity. Acts upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in cell leading edge; centriolar satellite; and ciliary basal body. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 30.6), liver E14 (RPKM 23.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 71.03 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146110397..146145899)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146404642..146440144)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
Title: OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
Title: The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac.
Title: Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.
localization at cell-cell adherens junctions
Title: ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

RH125146 (e-PCR)
- UniSTS:161968

AU042321 (e-PCR)
- UniSTS:159200

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intraciliary transport involved in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport involved in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in intraciliary transport involved in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: afadin- and alpha-actinin-binding protein

Names: SSX 2 interacting protein; afadin DIL domain-interacting protein; synovial sarcoma, X 2 interacting protein; synovial sarcoma, X breakpoint 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253768.2 → NP_001240697.1 afadin- and alpha-actinin-binding protein isoform b

See identical proteins and their annotated locations for NP_001240697.1

Status: VALIDATED

Source sequence(s)

AC124987, AK049080, AK077112, AK173064, BE945817

Consensus CDS

CCDS57260.1

UniProtKB/TrEMBL

A0A0R4J1A9, Q69ZV4

Related

ENSMUSP00000101755.2, ENSMUST00000106149.8

Conserved Domains (1) summary

pfam11559
Location:63 → 214

ADIP; Afadin- and alpha -actinin-Binding
NM_001253769.2 → NP_001240698.1 afadin- and alpha-actinin-binding protein isoform b

See identical proteins and their annotated locations for NP_001240698.1

Status: VALIDATED

Source sequence(s)

AC124987, AK043865, AK049080, AK173064, BE945817

Consensus CDS

CCDS57260.1

UniProtKB/TrEMBL

A0A0R4J1A9, Q69ZV4

Related

ENSMUSP00000101757.2, ENSMUST00000106151.8

Conserved Domains (1) summary

pfam11559
Location:63 → 214

ADIP; Afadin- and alpha -actinin-Binding
NM_001253770.2 → NP_001240699.1 afadin- and alpha-actinin-binding protein isoform b

See identical proteins and their annotated locations for NP_001240699.1

Status: VALIDATED

Source sequence(s)

AC124987, AK031356, AK049080, AK173064, BE945817

Consensus CDS

CCDS57260.1

UniProtKB/TrEMBL

A0A0R4J1A9, Q69ZV4

Related

ENSMUSP00000045663.5, ENSMUST00000039021.11

Conserved Domains (1) summary

pfam11559
Location:63 → 214

ADIP; Afadin- and alpha -actinin-Binding
NM_001355661.1 → NP_001342590.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

Consensus CDS

CCDS38665.1

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

UniProtKB/TrEMBL

Q69ZV4

Conserved Domains (2) summary

pfam11559
Location:63 → 214

ADIP; Afadin- and alpha -actinin-Binding

pfam17380
Location:140 → 301

DUF5401; Family of unknown function (DUF5401)
NM_001411104.1 → NP_001398033.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
NM_001411105.1 → NP_001398034.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
NM_001411107.1 → NP_001398036.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
NM_001411108.1 → NP_001398037.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
NM_001411109.1 → NP_001398038.1 afadin- and alpha-actinin-binding protein isoform a

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
NM_001411110.1 → NP_001398039.1 afadin- and alpha-actinin-binding protein isoform b

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/TrEMBL

A0A0R4J1A9
NM_001411114.1 → NP_001398043.1 afadin- and alpha-actinin-binding protein isoform b

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/TrEMBL

A0A0R4J1A9
NM_001411115.1 → NP_001398044.1 afadin- and alpha-actinin-binding protein isoform b

Status: VALIDATED

Source sequence(s)

AC124987

UniProtKB/TrEMBL

A0A0R4J1A9
NM_001411116.1 → NP_001398045.1 afadin- and alpha-actinin-binding protein isoform c

Status: VALIDATED

Source sequence(s)

AC124987
NM_001411117.1 → NP_001398046.1 afadin- and alpha-actinin-binding protein isoform c

Status: VALIDATED

Source sequence(s)

AC124987
NM_001411118.1 → NP_001398047.1 afadin- and alpha-actinin-binding protein isoform c

Status: VALIDATED

Source sequence(s)

AC124987
NM_001411119.1 → NP_001398048.1 afadin- and alpha-actinin-binding protein isoform d

Status: VALIDATED

Source sequence(s)

AC124987
NM_001411120.1 → NP_001398049.1 afadin- and alpha-actinin-binding protein isoform d

Status: VALIDATED

Source sequence(s)

AC124987
NM_001411121.1 → NP_001398050.1 afadin- and alpha-actinin-binding protein isoform e

Status: VALIDATED

Source sequence(s)

AC124987
NM_138744.4 → NP_620083.1 afadin- and alpha-actinin-binding protein isoform a

See identical proteins and their annotated locations for NP_620083.1

Status: VALIDATED

Source sequence(s)

AC124987, AK049080, AK173064, BE945817

Consensus CDS

CCDS38665.1

UniProtKB/Swiss-Prot

Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

UniProtKB/TrEMBL

Q69ZV4

Related

ENSMUSP00000101759.3, ENSMUST00000106153.9

Conserved Domains (2) summary

pfam11559
Location:63 → 214

ADIP; Afadin- and alpha -actinin-Binding

pfam17380
Location:140 → 301

DUF5401; Family of unknown function (DUF5401)