Grik3 glutamate receptor, ionotropic, kainate 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grik3provided by MGI
Official Full Name: glutamate receptor, ionotropic, kainate 3provided by MGI
Primary source: MGI:MGI:95816
See related: Ensembl:ENSMUSG00000001985 AllianceGenome:MGI:95816
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluK3; Glur7; Glur-7; GluR7-3; 9630027E11
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression: Biased expression in frontal lobe adult (RPKM 10.1), whole brain E14.5 (RPKM 9.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 58.91 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (125384025..125607966)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (125490259..125714173)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
Title: Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Title: Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
loss of FMRP leads to the abnormal function and localization of kainite receptors.
Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
Polarized trafficking of spliced variant GluK3b in neurons may be controlled by the regulation of receptor endocytosis.
Title: Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking.
GluR7, a kainate receptor (KAR) subunit with no known function in the brain, is identified as an essential subunit of presynaptic autoreceptors that facilitate hippocampal mossy fiber synaptic transmission.
Title: GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
GluR7 kainate receptor subunit splice variants differentially traffic from the ER to the plasma membrane
Title: Differential trafficking of GluR7 kainate receptor subunit splice variants.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit280 (e-PCR), detects polymorphism
- UniSTS:130071

D4Dcr24 (e-PCR), detects polymorphism
- UniSTS:507698

D11S4066 (e-PCR)
- UniSTS:154171

Glur7 (e-PCR)
- UniSTS:518639

D17S592 (e-PCR)
- UniSTS:65532

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEP Inferred from Expression Pattern more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 3

Names: glutamate receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081097.3 → NP_001074566.1 glutamate receptor ionotropic, kainate 3 precursor

See identical proteins and their annotated locations for NP_001074566.1

Status: REVIEWED

Source sequence(s)

AL607090, AL627328

Consensus CDS

CCDS38878.1

UniProtKB/Swiss-Prot

B1AS29, Q17R20, Q9JIA8

Related

ENSMUSP00000030676.8, ENSMUST00000030676.8

Conserved Domains (2) summary

cd06393
Location:34 → 417

PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor

cd13723
Location:433 → 801

PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

125384025..125607966

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502772.4 → XP_006502835.1 glutamate receptor ionotropic, kainate 3 isoform X1

Conserved Domains (2) summary

cd13723
Location:433 → 801

PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

cd06382
Location:37 → 417

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
XM_036163688.1 → XP_036019581.1 glutamate receptor ionotropic, kainate 3 isoform X3

Conserved Domains (2) summary

cd06382
Location:37 → 417

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:433 → 697

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_017319980.3 → XP_017175469.1 glutamate receptor ionotropic, kainate 3 isoform X2

Conserved Domains (2) summary

cd06382
Location:37 → 417

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:443 → 733

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily