Stk40 serine/threonine kinase 40 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk40provided by MGI
Official Full Name: serine/threonine kinase 40provided by MGI
Primary source: MGI:MGI:1921428
See related: Ensembl:ENSMUSG00000042608 AllianceGenome:MGI:1921428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310004N11Rik
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Acts upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; limb; and skin. Orthologous to human STK40 (serine/threonine kinase 40). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 18.0), lung adult (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 59.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (125997738..126034822)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126103942..126141029)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
Title: EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 and decrease in Gata1 proteins.
Title: Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver.
Loss of Stk40 is associated with impaired fetal skeletal muscle formation.
Title: Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.
CCAAT/enhancer-binding protein (C/EBP) beta and C/EBPdelta, two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40).
Title: Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins.
the results suggested that Stk40 may be critical in the development of preimplantation embryos.
Title: Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development.
Deletion of STK40 protein in mice causes respiratory failure and death at birth
Title: Deletion of STK40 protein in mice causes respiratory failure and death at birth.
report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells.
Title: Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

Stk40 (e-PCR), detects polymorphism
- UniSTS:472841

Stk40 (e-PCR), detects polymorphism
- UniSTS:472842

UniSTS:235027 (e-PCR)
- UniSTS:235027

RH126883 (e-PCR)
- UniSTS:207676

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase 40

Names: ortholog of Ser/Thr-like protein kinase Lyk4; serine/threonine-protein kinase lyk4

NP_001139299.1

EC 2.7.11.1

NP_083076.3

EC 2.7.11.1

XP_006503504.1

EC 2.7.11.1

XP_006503505.1

EC 2.7.11.1

XP_017175903.1

EC 2.7.11.1

XP_036020388.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145827.1 → NP_001139299.1 serine/threonine-protein kinase 40 isoform a

See identical proteins and their annotated locations for NP_001139299.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AL731780, AY336057, BQ030783, CJ170090, DV660319

Consensus CDS

CCDS51299.1

UniProtKB/Swiss-Prot

Q7TNL3

Related

ENSMUSP00000111990.3, ENSMUST00000116286.9

Conserved Domains (1) summary

cd13974
Location:52 → 344

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
NM_028800.3 → NP_083076.3 serine/threonine-protein kinase 40 isoform b

See identical proteins and their annotated locations for NP_083076.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AY336057, BQ030783, CJ170090, DV660319

Consensus CDS

CCDS51300.1

UniProtKB/Swiss-Prot

B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3

Related

ENSMUSP00000092354.5, ENSMUST00000094761.11

Conserved Domains (1) summary

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

125997738..126034822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320414.3 → XP_017175903.1 serine/threonine-protein kinase 40 isoform X2

UniProtKB/Swiss-Prot

B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3

Conserved Domains (1) summary

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
XM_006503442.3 → XP_006503505.1 serine/threonine-protein kinase 40 isoform X2

See identical proteins and their annotated locations for XP_006503505.1

UniProtKB/Swiss-Prot

B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3

Conserved Domains (1) summary

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
XM_006503441.5 → XP_006503504.1 serine/threonine-protein kinase 40 isoform X1

See identical proteins and their annotated locations for XP_006503504.1

UniProtKB/Swiss-Prot

Q7TNL3

Conserved Domains (1) summary

cd13974
Location:52 → 344

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
XM_036164495.1 → XP_036020388.1 serine/threonine-protein kinase 40 isoform X2

UniProtKB/Swiss-Prot

B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3

Conserved Domains (1) summary

cd13974
Location:38 → 330

STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase