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    Klhl5 kelch-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 71778, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl5provided by MGI
    Official Full Name
    kelch-like 5provided by MGI
    Primary source
    MGI:MGI:1919028
    See related
    Ensembl:ENSMUSG00000054920 AllianceGenome:MGI:1919028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300013C10Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including aorta; central nervous system; endocrine gland; esophagus; and limb interdigital region. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human KLHL5 (kelch like family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 16.4), CNS E18 (RPKM 7.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl5 in Genome Data Viewer
    Location:
    5 C3.1; 5 33.58 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65264894..65325490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65107551..65168173)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114, member A1 Neighboring gene STARR-seq mESC enhancer starr_13253 Neighboring gene STARR-seq mESC enhancer starr_13254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65397377-65397486 Neighboring gene predicted gene, 32374 Neighboring gene STARR-seq mESC enhancer starr_13256 Neighboring gene transmembrane protein 156 Neighboring gene STARR-seq mESC enhancer starr_13258 Neighboring gene STARR-seq mESC enhancer starr_13259 Neighboring gene predicted gene, 54287 Neighboring gene STARR-positive B cell enhancer ABC_E849 Neighboring gene WD repeat domain 19 Neighboring gene STARR-seq mESC enhancer starr_13260 Neighboring gene replication factor C (activator 1) 1 Neighboring gene STARR-positive B cell enhancer ABC_E6334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347355.1 → NP_001334284.1  kelch-like protein 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC132222
      Consensus CDS
      CCDS84883.1
      UniProtKB/TrEMBL
      E9Q1L2, Q571J4
      Related
      ENSMUSP00000144976.2, ENSMUST00000204097.3

    2. NM_001359401.1 → NP_001346330.1  kelch-like protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC132222, AK090246, BC057606
      Conserved Domains (2) summary
      pfam07707
      Location:275 → 370
      BACK; BTB And C-terminal Kelch
      cl28614
      Location:173 → 370
      BTB; Broad-Complex, Tramtrack and Bric a brac

    3. NM_175174.4 → NP_780383.2  kelch-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_780383.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI120540, BC057606
      Consensus CDS
      CCDS19305.2
      UniProtKB/TrEMBL
      E9QA66, Q6PFE1
      Related
      ENSMUSP00000098752.4, ENSMUST00000101191.10
      Conserved Domains (6) summary
      smart00612
      Location:562 → 608
      Kelch; Kelch domain
      PHA03098
      Location:173 → 695
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:457 → 500
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:163 → 266
      BTB; BTB/POZ domain
      pfam01344
      Location:456 → 501
      Kelch_1; Kelch motif
      pfam07707
      Location:275 → 374
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65264894..65325490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504134.5 → XP_006504197.1  kelch-like protein 5 isoform X1

      Conserved Domains (2) summary
      PHA03098
      Location:22 → 495
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:257 → 300
      Kelch; KELCH repeat [structural motif]

    2. XM_006504136.4 → XP_006504199.1  kelch-like protein 5 isoform X2

      Conserved Domains (2) summary
      cl38908
      Location:150 → 279
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:269 → 372
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. XM_036165496.1 → XP_036021389.1  kelch-like protein 5 isoform X1

      Conserved Domains (2) summary
      PHA03098
      Location:22 → 495
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:257 → 300
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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