Odaph odontogenesis associated phosphoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odaphprovided by MGI
Official Full Name: odontogenesis associated phosphoproteinprovided by MGI
Primary source: MGI:MGI:2685891
See related: Ensembl:ENSMUSG00000096035 AllianceGenome:MGI:2685891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1045; Gm1045-a; Gm1045-b
Summary: Predicted to be involved in positive regulation of enamel mineralization. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A4. Orthologous to human ODAPH (odontogenesis associated phosphoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 45.68 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (92135332..92143176)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (91987473..91995317)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Odontogenesis-Associated Phosphoprotein (ODAPH) Overexpression in Ameloblasts Disrupts Enamel Formation via Inducing Abnormal Mineralization of Enamel in Secretory Stage.
Title: Odontogenesis-Associated Phosphoprotein (ODAPH) Overexpression in Ameloblasts Disrupts Enamel Formation via Inducing Abnormal Mineralization of Enamel in Secretory Stage.
Maturation stage enamel defects in Odontogenesis-associated phosphoprotein (Odaph) deficient mice.
Title: Maturation stage enamel defects in Odontogenesis-associated phosphoprotein (Odaph) deficient mice.
Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in Odaph(C41*/C41*) mice.
Title: Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in Odaph(C41*/C41*) mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of enamel mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of enamel mineralization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: odontogenesis associated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177577.1 → NP_001171048.1 odontogenesis associated phosphoprotein precursor

Status: VALIDATED

Source sequence(s)

AC165433

Consensus CDS

CCDS57356.1

UniProtKB/TrEMBL

A0A075DD83, J3QNT8

Related

ENSMUSP00000136951.2, ENSMUST00000178614.3

Conserved Domains (1) summary

pfam15848
Location:24 → 105

DUF4721; Domain of unknown function (DUF4721)