Iigp1 interferon inducible GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iigp1provided by MGI
Official Full Name: interferon inducible GTPase 1provided by MGI
Primary source: MGI:MGI:1926259
See related: Ensembl:ENSMUSG00000054072 AllianceGenome:MGI:1926259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iigp; Irga6; Ifgga1; 2900074L10Rik
Summary: Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is active in cytoplasm. Is expressed in several structures, including foregut; genitourinary system; heart; limb; and respiratory system. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 22.2), liver adult (RPKM 9.9) and 4 other tissues See more
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Genomic context

Location:: 18 D3; 18 34.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (60506688..60525706)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60373616..60392634)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
Title: Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
The study determined the crystal structure of an oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable GTP analog.
Title: The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion.
These data identify Toxoplasma gondii GRA7 as a regulator for ROP18-specific inactivation of murine Irga6.
Title: The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.
ROP5 uses a highly polymorphic surface to bind adjacent to the nucleotide-binding domain of an IRG and that this produces a profound allosteric change in the IRGa6 structure. [Rop5]
Title: The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.
This study defines the catalytic G-domain interface by mutagenesis and presents a model of how GTP hydrolysis is activated in Irga6 complexes, based on the substrate-twinning reaction mechanism of the signal recognition particle and its receptor (SRalpha).
Title: The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.
Toxoplasma gondii ROP5 binding alters the conformation of the Irga6 active site.
Title: A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.
results implicate Irga6 in the control of infection with T. gondii and further highlight the importance of the IRG system for resistance to this pathogen
Title: The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.
Virulent T. gondii strain ROP18 kinase phosphorylates host Irga6 at two threonines in the nucleotide-binding domain, biochemically inactivating the GTPase and inhibiting its accumulation and action at the T. gondii parasitophorous vacuole membrane.
Title: Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.
role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system
Title: A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
Differential induction by various gram-negative lipopolysaccharides was myeloid differentiation factor 88 (MyD88)-independent
Title: Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Iigp1 (e-PCR), detects polymorphism
- UniSTS:506999

AI046432 (e-PCR)
- UniSTS:181124

AW111922 (e-PCR)
- UniSTS:181125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in symbiont-containing vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon-inducible GTPase 1

Names: interferon-gamma-inducible GTPase Ifgga1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146275.1 → NP_001139747.1 interferon-inducible GTPase 1

See identical proteins and their annotated locations for NP_001139747.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC151990, AF194871, AJ007971, AK153060, DV061261

Consensus CDS

CCDS29270.1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Related

ENSMUSP00000032473.7, ENSMUST00000032473.7

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
NM_021792.5 → NP_068564.4 interferon-inducible GTPase 1

See identical proteins and their annotated locations for NP_068564.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC151990, AF194871, AJ007971, AK153060

Consensus CDS

CCDS29270.1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

60506688..60525706

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246978.4 → XP_011245280.1 interferon-inducible GTPase 1 isoform X1

See identical proteins and their annotated locations for XP_011245280.1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
XM_011246980.3 → XP_011245282.1 interferon-inducible GTPase 1 isoform X1

See identical proteins and their annotated locations for XP_011245282.1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
XM_030250557.2 → XP_030106417.1 interferon-inducible GTPase 1 isoform X1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Related

ENSMUSP00000063390.6, ENSMUST00000066912.13

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
XM_011246979.4 → XP_011245281.1 interferon-inducible GTPase 1 isoform X1

See identical proteins and their annotated locations for XP_011245281.1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
XM_030250559.2 → XP_030106419.1 interferon-inducible GTPase 1 isoform X1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)
XM_036161227.1 → XP_036017120.1 interferon-inducible GTPase 1 isoform X1

UniProtKB/Swiss-Prot

Q9QZ85, Q9Z1M3

UniProtKB/TrEMBL

J7NNX8, U5NG72

Related

ENSMUSP00000157568.2, ENSMUST00000237185.2

Conserved Domains (1) summary

pfam05049
Location:35 → 409

IIGP; Interferon-inducible GTPase (IIGP)