Tlr6 toll-like receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr6provided by MGI
Official Full Name: toll-like receptor 6provided by MGI
Primary source: MGI:MGI:1341296
See related: Ensembl:ENSMUSG00000051498 AllianceGenome:MGI:1341296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables diacyl lipopeptide binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of biosynthetic process; and positive regulation of defense response. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in brain; cerebral cortex; embryo; and telencephalon. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 3.6), colon adult (RPKM 1.8) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 33.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (65109373..65128387, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (64953092..64970942, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-kappaB Response.
Title: Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response.
Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer.
Title: Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer.
TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.
Title: TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.
TLR2 and TLR6 are upregulated in ischemic muscle and play a role in ischemia-induced muscle damage.
Title: Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes.
Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.
Title: Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.
findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium
Title: Mycobacterium lepraemurium uses TLR-6 and MR, but not lipid rafts or DC-sign, to gain access into mouse macrophages.
recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6.
Title: Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.
the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined.
Title: TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.
Data suggest that the transmembrane domains of Tlr4 and Tlr6 have essential roles in Tlr4/Tlr6/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
Title: Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition.
Title: Toll-like receptor-6 (TLR6) deficient mice are protected from myocardial fibrosis induced by high fructose feeding through anti-oxidant and inflammatory signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (4) 1 citation
Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables diacyl lipopeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopeptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in TRIF-dependent toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-12 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of macrophage activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterial lipoprotein	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor TLR6:TLR2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 6

NP_001346109.2

EC 3.2.2.6

NP_001371100.1

EC 3.2.2.6

NP_035734.4

EC 3.2.2.6

XP_030110224.1

EC 3.2.2.6

XP_036020888.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359180.3 → NP_001346109.2 toll-like receptor 6 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein.

Source sequence(s)

AC161757

UniProtKB/Swiss-Prot

Q9EPW9, Q9WTQ4

UniProtKB/TrEMBL

Q7TPC5

Conserved Domains (6) summary

smart00082
Location:529 → 583

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:641 → 780

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:39 → 529

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:54 → 77

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:379 → 404

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:76 → 133

LRR_8; Leucine rich repeat
NM_001384171.2 → NP_001371100.1 toll-like receptor 6 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 all encode the same protein.

Source sequence(s)

AC161757

UniProtKB/Swiss-Prot

Q9EPW9, Q9WTQ4

UniProtKB/TrEMBL

Q7TPC5

Conserved Domains (6) summary

smart00082
Location:529 → 583

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:641 → 780

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:39 → 529

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:54 → 77

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:379 → 404

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:76 → 133

LRR_8; Leucine rich repeat
NM_011604.6 → NP_035734.4 toll-like receptor 6 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein.

Source sequence(s)

AC161757

UniProtKB/Swiss-Prot

Q9EPW9, Q9WTQ4

UniProtKB/TrEMBL

Q7TPC5

Related

ENSMUSP00000062096.6, ENSMUST00000062315.7

Conserved Domains (6) summary

smart00082
Location:529 → 583

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:641 → 780

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:39 → 529

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:54 → 77

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:379 → 404

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:76 → 133

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

65109373..65128387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254364.2 → XP_030110224.1 toll-like receptor 6 isoform X1

UniProtKB/TrEMBL

Q3UV88, Q7TPC5

Conserved Domains (6) summary

smart00082
Location:540 → 594

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:652 → 791

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:50 → 540

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:65 → 88

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:390 → 415

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 144

LRR_8; Leucine rich repeat
XM_036164995.1 → XP_036020888.1 toll-like receptor 6 isoform X1

UniProtKB/TrEMBL

Q3UV88, Q7TPC5

Conserved Domains (6) summary

smart00082
Location:540 → 594

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:652 → 791

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:50 → 540

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:65 → 88

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:390 → 415

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 144

LRR_8; Leucine rich repeat