Ak1 adenylate kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ak1provided by MGI
Official Full Name: adenylate kinase 1provided by MGI
Primary source: MGI:MGI:87977
See related: Ensembl:ENSMUSG00000026817 AllianceGenome:MGI:87977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ak-1; B430205N08Rik
Summary: Enables adenylate kinase activity. Predicted to be involved in inosine biosynthetic process; positive regulation of D-glucose transmembrane transport; and purine ribonucleotide metabolic process. Located in outer dense fiber. Is expressed in several structures, including heart; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 107.3), testis adult (RPKM 39.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32511770..32525070)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32621758..32635058)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
Title: The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
Title: Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stressdagger.
Title: Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress†.
In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme.
Title: Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.
CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
Title: CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides
Title: Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.
Title: Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase.
Adenylate kinase-1 knockout mice have a normal capacity for contraction-mediated glucose uptake.
Title: Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice.
Defective metabolic signaling in Ak1 gene knock-out hearts compromises post-ischemic coronary reflow.
Title: Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow.
The purpose of this study was to determine whether adenylate kinase 1 deficiency would result in sufficient ADP accumulation to be visible using (31)P-NMRS during the high energy demands of frequent in situ tetanic contractions.
Title: 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC305872P1 (e-PCR)
- UniSTS:272566

NoName (e-PCR)
- UniSTS:238051

RH137043 (e-PCR)
- UniSTS:219132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (deoxy)adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to phosphotransferase activity, phosphate group as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ADP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in inosine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in outer dense fiber	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate kinase isoenzyme 1

Names: cytosolic adenylate kinase

NP_001185719.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

NP_001185720.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

NP_001185721.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

NP_067490.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_030102669.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_036013552.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198790.1 → NP_001185719.1 adenylate kinase isoenzyme 1 isoform 2

See identical proteins and their annotated locations for NP_001185719.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).

Source sequence(s)

AK046613, BC014802

Consensus CDS

CCDS57167.1

UniProtKB/Swiss-Prot

A2AK80, Q542C5, Q9R0Y4, Q9R0Y5

Related

ENSMUSP00000108903.3, ENSMUST00000113278.9

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
NM_001198791.1 → NP_001185720.1 adenylate kinase isoenzyme 1 isoform 2

See identical proteins and their annotated locations for NP_001185720.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).

Source sequence(s)

BC014802, BY130582

Consensus CDS

CCDS57167.1

UniProtKB/Swiss-Prot

A2AK80, Q542C5, Q9R0Y4, Q9R0Y5

Related

ENSMUSP00000108902.2, ENSMUST00000113277.8

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
NM_001198792.1 → NP_001185721.1 adenylate kinase isoenzyme 1 isoform 2

See identical proteins and their annotated locations for NP_001185721.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).

Source sequence(s)

BC014802, BY333336

Consensus CDS

CCDS57167.1

UniProtKB/Swiss-Prot

A2AK80, Q542C5, Q9R0Y4, Q9R0Y5

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
NM_021515.3 → NP_067490.1 adenylate kinase isoenzyme 1 isoform 1

See identical proteins and their annotated locations for NP_067490.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

BC014802, CF950379

Consensus CDS

CCDS15924.1

UniProtKB/Swiss-Prot

Q9R0Y5

Related

ENSMUSP00000068479.5, ENSMUST00000068271.5

Conserved Domains (1) summary

TIGR01360
Location:22 → 209

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

32511770..32525070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246809.2 → XP_030102669.1 adenylate kinase isoenzyme 1 isoform X1

UniProtKB/Swiss-Prot

A2AK80, Q542C5, Q9R0Y4, Q9R0Y5

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
XM_036157659.1 → XP_036013552.1 adenylate kinase isoenzyme 1 isoform X1

UniProtKB/Swiss-Prot

A2AK80, Q542C5, Q9R0Y4, Q9R0Y5

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily