Sec1 secretory blood group 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec1provided by MGI
Official Full Name: secretory blood group 1provided by MGI
Primary source: MGI:MGI:1928893
See related: Ensembl:ENSMUSG00000040364 AllianceGenome:MGI:1928893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fut3; Fut10
Summary: This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. This gene is predicted to encode a type II membrane protein, which is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. [provided by RefSeq, Dec 2012]
Expression: Biased expression in testis adult (RPKM 22.6), colon adult (RPKM 8.4) and 4 other tissues See more
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Genomic context

Location:: 7 B3; 7 29.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45327110..45343825, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45677686..45694402, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
Title: Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
Title: Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
E-selectin binding activity mediated by the alpha1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone.
Title: Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.
amino acid sequence and expression
Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235664

NoName (e-PCR)
- UniSTS:485271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactoside 2-alpha-L-fucosyltransferase Sec1

Names: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III; alpha(1,2)FT 3; fucosyltransferase 10; galactoside 2-alpha-L-fucosyltransferase 3

NP_001258507.1

EC 2.4.1.69

NP_001392824.1

EC 2.4.1.69

XP_006541073.1

EC 2.4.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271578.2 → NP_001258507.1 galactoside 2-alpha-L-fucosyltransferase Sec1

Status: VALIDATED

Source sequence(s)

AC167242

Consensus CDS

CCDS71963.1

UniProtKB/TrEMBL

Q496T8, Q8CDC9

Related

ENSMUSP00000045229.7, ENSMUST00000040636.9

Conserved Domains (1) summary

pfam01531
Location:55 → 362

Glyco_transf_11; Glycosyl transferase family 11
NM_001405895.1 → NP_001392824.1 galactoside 2-alpha-L-fucosyltransferase Sec1

Status: VALIDATED

Source sequence(s)

AC167242

UniProtKB/TrEMBL

Q8CDC9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45327110..45343825 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541010.4 → XP_006541073.1 galactoside 2-alpha-L-fucosyltransferase Sec1 isoform X2

UniProtKB/TrEMBL

Q496T8

Conserved Domains (1) summary

pfam01531
Location:4 → 277

Glyco_transf_11; Glycosyl transferase family 11

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019934.2: Suppressed sequence

Description

NM_019934.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.