Rps23rg1 ribosomal protein S23, retrogene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps23rg1provided by MGI
Official Full Name: ribosomal protein S23, retrogene 1provided by MGI
Primary source: MGI:MGI:3612471
See related: Ensembl:ENSMUSG00000065952 AllianceGenome:MGI:3612471
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rps23r1; 2610027C06Rik; C330021F23Rik
Summary: Enables adenylate cyclase binding activity. Acts upstream of or within amyloid-beta metabolic process; negative regulation of protein metabolic process; and positive regulation of cAMP/PKA signal transduction. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 155.9), CNS E11.5 (RPKM 107.6) and 25 other tissues See more
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3617998..3634776)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3567998..3584776)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Title: RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
The study results reveal a role for RPS23RG1 in maintaining synaptic integrity and function and provide a new mechanism for synaptic dysfunction in Alzheimer's disease (AD) pathogenesis.
Title: RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.
Our study demonstrates that RPS23RG1 may reduce the occurrence of key elements of AD pathology and enhance synaptic functions to counteract oAbeta-induced synaptic and cognitive deficits in AD
Title: RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits.
We provide compelling evidence to show that RPS23R1 overexpression can reduce both beta-amyloid levels and tau phosphorylation, two major pathological hallmarks of Alzheimer's disease
Title: A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within amyloid-beta metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S23, retrogene 1

Names: ribosomal protein S23 like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.