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    Lrrc36 leucine rich repeat containing 36 [ Mus musculus (house mouse) ]

    Gene ID: 270091, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc36provided by MGI
    Official Full Name
    leucine rich repeat containing 36provided by MGI
    Primary source
    MGI:MGI:2448585
    See related
    Ensembl:ENSMUSG00000054320 AllianceGenome:MGI:2448585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Orthologous to human LRRC36 (leucine rich repeat containing 36). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 27.0), lung adult (RPKM 2.4) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc36 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106140230..106190718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105413598..105464086)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene zinc finger, DHHC domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033371.3 → NP_001028543.1  leucine-rich repeat-containing protein 36 isoform 3

      See identical proteins and their annotated locations for NP_001028543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks a 2 residue internal segment, compared to isoform 1.
      Source sequence(s)
      AK133042, BC036564
      Consensus CDS
      CCDS22601.1
      UniProtKB/Swiss-Prot
      Q3V0M2
      Related
      ENSMUSP00000066345.7, ENSMUST00000067305.8

    2. NM_001170788.1 → NP_001164259.1  leucine-rich repeat-containing protein 36 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090480, BC036564, BC172120, BY084860
      Consensus CDS
      CCDS52658.1
      UniProtKB/TrEMBL
      A0A1L1SRB0, F8WI85
      Related
      ENSMUSP00000104979.3, ENSMUST00000109355.9
      Conserved Domains (3) summary
      cd00116
      Location:42 → 107
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    3. NM_001170789.1 → NP_001164260.1  leucine-rich repeat-containing protein 36 isoform 2

      See identical proteins and their annotated locations for NP_001164260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK133042, BC036564, BC172120
      UniProtKB/TrEMBL
      B7ZWL7

    4. NM_001402748.1 → NP_001389677.1  leucine-rich repeat-containing protein 36 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090480

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106140230..106190718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531057.3 → XP_006531120.1  leucine-rich repeat-containing protein 36 isoform X3

      UniProtKB/TrEMBL
      A0A1L1SRB0
      Conserved Domains (2) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:44 → 148
      LRR_9; Leucine-rich repeat

    2. XM_006531055.3 → XP_006531118.1  leucine-rich repeat-containing protein 36 isoform X1

      See identical proteins and their annotated locations for XP_006531118.1

      UniProtKB/Swiss-Prot
      B2RX53, Q3V0M2
      UniProtKB/TrEMBL
      A0A1L1SRB0
      Related
      ENSMUSP00000150103.2, ENSMUST00000213547.2
      Conserved Domains (2) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:44 → 148
      LRR_9; Leucine-rich repeat

    3. XM_006531056.3 → XP_006531119.1  leucine-rich repeat-containing protein 36 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SRB0
      Conserved Domains (2) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:44 → 148
      LRR_9; Leucine-rich repeat

    4. XM_036154082.1 → XP_036009975.1  leucine-rich repeat-containing protein 36 isoform X5

      Conserved Domains (2) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:50 → 141
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. XR_387748.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0M2.2 GenPept UniProtKB/Swiss-Prot:Q3V0M2

    Gene LinkOut

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