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    Zim1 zinc finger, imprinted 1 [ Mus musculus (house mouse) ]

    Gene ID: 22776, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zim1provided by MGI
    Official Full Name
    zinc finger, imprinted 1provided by MGI
    Primary source
    MGI:MGI:1341879
    See related
    Ensembl:ENSMUSG00000002266 AllianceGenome:MGI:1341879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; limb; and submandibular gland primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 16.9), placenta adult (RPKM 4.9) and 8 other tissues See more
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    Genomic context

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    See Zim1 in Genome Data Viewer
    Location:
    7 A1; 7 3.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6677443..6699521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6674444..6696540, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17982 Neighboring gene olfactory receptor family 5 subfamily BW member 2 Neighboring gene zinc finger, imprinted 2 Neighboring gene STARR-seq mESC enhancer starr_17985 Neighboring gene Peg3 opposite strand Neighboring gene paternally expressed 3 Neighboring gene Tctex1 domain containing 2 pseudogene Neighboring gene ubiquitin specific peptidase 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zim1, a maternally expressed mouse Kruppel-type zinc-finger gene located in proximal chromosome 7. Kim J, et al. Hum Mol Genet, 1999 May. PMID 10196374
    2. Trans-allelic mutational effects at the Peg3 imprinted locus. Bretz CL, et al. PLoS One, 2018. PMID 30335829, Free PMC Article
    3. A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior. Denizot AL, et al. PLoS Genet, 2016 May. PMID 27187722, Free PMC Article
    4. Analysis of imprinted murine Peg3 locus in transgenic mice. Szeto IY, et al. Mamm Genome, 2004 Apr. PMID 15112106
    5. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. Kim J, et al. Genome Res, 2000 Aug. PMID 10958632, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger, imprinted 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011769.4 → NP_035899.4  zinc finger, imprinted 1

      See identical proteins and their annotated locations for NP_035899.4

      Status: VALIDATED

      Source sequence(s)
      AK086590, BC066196, CD349354
      Consensus CDS
      CCDS20782.1
      UniProtKB/TrEMBL
      Q8C393
      Related
      ENSMUSP00000002336.9, ENSMUST00000002336.16
      Conserved Domains (5) summary
      PRK13335
      Location:137 → 269
      PRK13335; superantigen-like protein SSL3; Reviewed
      smart00349
      Location:50 → 105
      KRAB; krueppel associated box
      COG5048
      Location:226 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6677443..6699521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250495.3 → XP_011248797.1  zinc finger, imprinted 1 isoform X1

      See identical proteins and their annotated locations for XP_011248797.1

      UniProtKB/TrEMBL
      Q8C393
      Conserved Domains (5) summary
      PRK13335
      Location:137 → 269
      PRK13335; superantigen-like protein SSL3; Reviewed
      smart00349
      Location:50 → 105
      KRAB; krueppel associated box
      COG5048
      Location:226 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_011250499.3 → XP_011248801.1  zinc finger, imprinted 1 isoform X1

      See identical proteins and their annotated locations for XP_011248801.1

      UniProtKB/TrEMBL
      Q8C393
      Conserved Domains (5) summary
      PRK13335
      Location:137 → 269
      PRK13335; superantigen-like protein SSL3; Reviewed
      smart00349
      Location:50 → 105
      KRAB; krueppel associated box
      COG5048
      Location:226 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_011250498.3 → XP_011248800.1  zinc finger, imprinted 1 isoform X2

      Conserved Domains (4) summary
      PRK13335
      Location:59 → 191
      PRK13335; superantigen-like protein SSL3; Reviewed
      COG5048
      Location:148 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:249 → 269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 27
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_011250497.3 → XP_011248799.1  zinc finger, imprinted 1 isoform X1

      See identical proteins and their annotated locations for XP_011248799.1

      UniProtKB/TrEMBL
      Q8C393
      Conserved Domains (5) summary
      PRK13335
      Location:137 → 269
      PRK13335; superantigen-like protein SSL3; Reviewed
      smart00349
      Location:50 → 105
      KRAB; krueppel associated box
      COG5048
      Location:226 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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