Spata33 spermatogenesis associated 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata33provided by MGI
Official Full Name: spermatogenesis associated 33provided by MGI
Primary source: MGI:MGI:2444920
See related: Ensembl:ENSMUSG00000048478 AllianceGenome:MGI:2444920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732415M23Rik
Summary: Involved in mitophagy. Acts upstream of or within fertilization; flagellated sperm motility; and protein localization. Located in male germ cell nucleus; mitochondrion; and sperm mitochondrial sheath. Orthologous to human SPATA33 (spermatogenesis associated 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 40.6) and heart adult (RPKM 1.9) See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 72.08 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123939572..123948784)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (123212837..123222045)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
Title: SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
Title: SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
Results indicate that Spata33 was predominantly expressed in the testis and associated with spermatogenesis.
Title: A novel testis-enriched gene Spata33 is expressed during spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spermatogenesis-associated protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.