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    Mtnr1b melatonin receptor 1B [ Mus musculus (house mouse) ]

    Gene ID: 244701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtnr1bprovided by MGI
    Official Full Name
    melatonin receptor 1Bprovided by MGI
    Primary source
    MGI:MGI:2181726
    See related
    Ensembl:ENSMUSG00000050901 AllianceGenome:MGI:2181726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mt2; Mel1b; Mel-1B-R
    Summary
    Predicted to enable melatonin receptor activity. Predicted to be involved in several processes, including negative regulation of cell communication; positive regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of transmission of nerve impulse. Predicted to act upstream of or within circadian rhythm. Predicted to be active in plasma membrane. Is expressed in alimentary system; central nervous system; eye; and reproductive system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mtnr1b in Genome Data Viewer
    Location:
    9 A2; 9 5.15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15773910..15785852, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15862614..15874556, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene FAT atypical cadherin 3 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499 Neighboring gene STARR-seq mESC enhancer starr_23398 Neighboring gene STARR-seq mESC enhancer starr_23400 Neighboring gene STARR-seq mESC enhancer starr_23401 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A. Zhao S, et al. Int J Mol Sci, 2024 Jan 5. PMID 38255808, Free PMC Article
    2. The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors. Pfeffer M, et al. Chronobiol Int, 2012 May. PMID 22489607
    3. Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Chern CM, et al. Free Radic Biol Med, 2012 May 1. PMID 22330064
    4. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. Tuomi T, et al. Cell Metab, 2016 Jun 14. PMID 27185156
    5. Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin. Cernysiov V, et al. Int Immunol, 2010 Jan. PMID 19946015

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
      Title: Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
    2. Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
      Title: Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
    3. The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
      Title: The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
    4. Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
      Title: Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
    5. Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
      Title: Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
    6. Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT2 receptors.
      Title: Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin  MT(2) receptors.
    7. Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
      Title: Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT(2) receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
    8. Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.
      Title: Nociceptive responses in melatonin MT(2) receptor knockout mice compared to MT(1) and double MT(1) /MT(2) receptor knockout mice.
    9. Changes in melatonin receptor expression in a murine model of glaucoma.
      Title: Changes in melatonin receptor expression in a murine model of glaucoma.
    10. Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain.
      Title: Pharmacological evidence for transactivation within melatonin MT(2) and serotonin 5-HT(2C) receptor heteromers in mouse brain.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129286, MGC129287

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables melatonin receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    melatonin receptor type 1B
    Names
    MT2 melatonin receptor
    Mel-1b melatonin receptor
    mel1b receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145712.2 → NP_663758.2  melatonin receptor type 1B

      See identical proteins and their annotated locations for NP_663758.2

      Status: VALIDATED

      Source sequence(s)
      AB377276
      Consensus CDS
      CCDS22841.1
      UniProtKB/Swiss-Prot
      Q80T38, Q8CIQ6, Q8K3K0
      UniProtKB/TrEMBL
      Q3SXF8
      Related
      ENSMUSP00000053086.6, ENSMUST00000057920.7
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:55 → 192
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15773910..15785852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIQ6.1 GenPept UniProtKB/Swiss-Prot:Q8CIQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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