Stard8 StAR related lipid transfer domain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard8provided by MGI
Official Full Name: StAR related lipid transfer domain containing 8provided by MGI
Primary source: MGI:MGI:2448556
See related: Ensembl:ENSMUSG00000031216 AllianceGenome:MGI:2448556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlc3; mKIAA0189
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to be located in focal adhesion. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 27.0), kidney adult (RPKM 19.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.19 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (98046539..98118334)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (99002933..99074728)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 8

Names: START domain containing 8; START domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199018.2 → NP_950183.1 stAR-related lipid transfer protein 8

Status: VALIDATED

Source sequence(s)

AK149830, BC062944, BY251063

Consensus CDS

CCDS30297.1

UniProtKB/Swiss-Prot

B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8

Related

ENSMUSP00000044491.8, ENSMUST00000036606.14

Conserved Domains (2) summary

cl02570
Location:565 → 779

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:806 → 1010

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

98046539..98118334

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527998.2 → XP_006528061.1 stAR-related lipid transfer protein 8 isoform X1

Conserved Domains (3) summary

cd09538
Location:31 → 90

SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily

cl02570
Location:645 → 859

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:886 → 1090

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036161930.1 → XP_036017823.1 stAR-related lipid transfer protein 8 isoform X5

UniProtKB/Swiss-Prot

B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8

Conserved Domains (2) summary

cl02570
Location:565 → 779

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:806 → 1010

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006528002.3 → XP_006528065.1 stAR-related lipid transfer protein 8 isoform X3

Conserved Domains (2) summary

cl02570
Location:572 → 786

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:813 → 1017

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006528005.3 → XP_006528068.1 stAR-related lipid transfer protein 8 isoform X6

Conserved Domains (2) summary

cl02570
Location:552 → 766

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:793 → 997

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_030251326.2 → XP_030107186.1 stAR-related lipid transfer protein 8 isoform X5

UniProtKB/Swiss-Prot

B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8

Conserved Domains (2) summary

cl02570
Location:565 → 779

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:806 → 1010

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036161931.1 → XP_036017824.1 stAR-related lipid transfer protein 8 isoform X5

UniProtKB/Swiss-Prot

B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8

Conserved Domains (2) summary

cl02570
Location:565 → 779

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:806 → 1010

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006528006.3 → XP_006528069.1 stAR-related lipid transfer protein 8 isoform X6

Conserved Domains (2) summary

cl02570
Location:552 → 766

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:793 → 997

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006527999.5 → XP_006528062.1 stAR-related lipid transfer protein 8 isoform X2

Conserved Domains (3) summary

cd09538
Location:27 → 86

SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily

cl02570
Location:641 → 855

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:882 → 1086

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006528003.5 → XP_006528066.1 stAR-related lipid transfer protein 8 isoform X4

Conserved Domains (2) summary

cl02570
Location:571 → 785

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:812 → 1016

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006528007.3 → XP_006528070.1 stAR-related lipid transfer protein 8 isoform X5

UniProtKB/Swiss-Prot

B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8

Conserved Domains (2) summary

cl02570
Location:565 → 779

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14643
Location:806 → 1010

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily