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    ARHGAP21 Rho GTPase activating protein 21 [ Homo sapiens (human) ]

    Gene ID: 57584, updated on 3-Dec-2024

    Summary

    Official Symbol
    ARHGAP21provided by HGNC
    Official Full Name
    Rho GTPase activating protein 21provided by HGNC
    Primary source
    HGNC:HGNC:23725
    See related
    Ensembl:ENSG00000107863 MIM:609870; AllianceGenome:HGNC:23725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHGAP10
    Summary
    ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGAP21 in Genome Data Viewer
    Location:
    10p12.1; 10p12.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (24583614..24723887, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (24602382..24742515, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (24872543..25012816, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene KIAA1217 Neighboring gene uncharacterized LOC105376455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:24751397-24751898 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11630 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:24782535-24783036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:24783037-24783536 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:24783692-24784472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:24790381-24790881 Neighboring gene uncharacterized LOC124902394 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:24821078-24822277 Neighboring gene Sharpr-MPRA regulatory region 10635 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:24847550-24847997 Neighboring gene NANOG hESC enhancer GRCh37_chr10:24868778-24869279 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:24901387-24901576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2222 Neighboring gene RNA, 5S ribosomal pseudogene 305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2224 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:25012349-25013259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2228 Neighboring gene coenzyme Q10B pseudogene 1 Neighboring gene uncharacterized LOC105376456 Neighboring gene MPRA-validated peak910 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:25051766-25052318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3160 Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene RN7SK pseudogene 241

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ33323, FLJ90108, DKFZp761L0424

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of Golgi localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maintenance of Golgi location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 21
    Names
    Rho-GTPase activating protein 10
    rho GTPase-activating protein 10
    rho-type GTPase-activating protein 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367447.1NP_001354376.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
      Consensus CDS
      CCDS91222.1
      UniProtKB/TrEMBL
      A0A2X0SF83, A0A805TBS0
    2. NM_001367448.1NP_001354377.1  rho GTPase-activating protein 21 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AL355979, AL392104
      Consensus CDS
      CCDS7144.2
      UniProtKB/Swiss-Prot
      Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
      UniProtKB/TrEMBL
      A0A2X0SF83
      Related
      ENSP00000506388.1, ENST00000680286.1
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    3. NM_001367449.1NP_001354378.1  rho GTPase-activating protein 21 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.
      Source sequence(s)
      AL355979, AL392104
      UniProtKB/TrEMBL
      A0A2X0SF83
    4. NM_001367450.1NP_001354379.1  rho GTPase-activating protein 21 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AL355979, AL392104
      UniProtKB/TrEMBL
      A0A2X0SF83
    5. NM_001367451.1NP_001354380.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
      Consensus CDS
      CCDS91222.1
      UniProtKB/TrEMBL
      A0A2X0SF83, A0A805TBS0
      Related
      ENSP00000365592.3, ENST00000376410.7
    6. NM_001367452.1NP_001354381.1  rho GTPase-activating protein 21 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
      UniProtKB/TrEMBL
      A0A2X0SF83
    7. NM_001367453.1NP_001354382.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
      Consensus CDS
      CCDS91222.1
      UniProtKB/TrEMBL
      A0A2X0SF83, A0A805TBS0
    8. NM_001367454.1NP_001354383.1  rho GTPase-activating protein 21 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AL355979, AL392104
      Consensus CDS
      CCDS7144.2
      UniProtKB/Swiss-Prot
      Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    9. NM_001367455.1NP_001354384.1  rho GTPase-activating protein 21 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL392104
      UniProtKB/TrEMBL
      A0A2X0SF83
      Related
      ENST00000486374.5
    10. NM_020824.4NP_065875.3  rho GTPase-activating protein 21 isoform a

      See identical proteins and their annotated locations for NP_065875.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AB037845, AF480466, AL355979, AV709499, BI491305, BQ026288
      Consensus CDS
      CCDS7144.2
      UniProtKB/Swiss-Prot
      Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
      UniProtKB/TrEMBL
      A0A2X0SF83
      Related
      ENSP00000379709.2, ENST00000396432.7
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

    RNA

    1. NR_160021.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    2. NR_160022.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    3. NR_160023.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    4. NR_160024.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL392104
    5. NR_160025.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL392104

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      24583614..24723887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425561.1XP_047281517.1  rho GTPase-activating protein 21 isoform X7

    2. XM_011519605.3XP_011517907.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11681363
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9571066
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9581063
      PH; PH domain
    3. XM_047425560.1XP_047281516.1  rho GTPase-activating protein 21 isoform X6

    4. XM_011519607.3XP_011517909.1  rho GTPase-activating protein 21 isoform X4

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    5. XM_011519602.3XP_011517904.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517904.1

      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    6. XM_047425562.1XP_047281518.1  rho GTPase-activating protein 21 isoform X7

    7. XM_047425557.1XP_047281513.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
    8. XM_011519604.3XP_011517906.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517906.1

      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    9. XM_047425556.1XP_047281512.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
    10. XM_011519603.4XP_011517905.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517905.1

      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    11. XM_011519606.3XP_011517908.1  rho GTPase-activating protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF83
      Conserved Domains (4) summary
      cd00992
      Location:3487
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11101305
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:8991008
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9001005
      PH; PH domain
    12. XM_047425563.1XP_047281519.1  rho GTPase-activating protein 21 isoform X8

      UniProtKB/TrEMBL
      A0A1B0GV73
      Related
      ENSP00000490396.1, ENST00000636789.1
    13. XM_047425559.1XP_047281515.1  rho GTPase-activating protein 21 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV73

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      24602382..24742515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366417.1XP_054222392.1  rho GTPase-activating protein 21 isoform X7

    2. XM_054366410.1XP_054222385.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
    3. XM_054366416.1XP_054222391.1  rho GTPase-activating protein 21 isoform X6

    4. XM_054366414.1XP_054222389.1  rho GTPase-activating protein 21 isoform X4

    5. XM_054366407.1XP_054222382.1  rho GTPase-activating protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF83
    6. XM_054366418.1XP_054222393.1  rho GTPase-activating protein 21 isoform X7

    7. XM_054366412.1XP_054222387.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
    8. XM_054366409.1XP_054222384.1  rho GTPase-activating protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF83
    9. XM_054366411.1XP_054222386.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF83
    10. XM_054366408.1XP_054222383.1  rho GTPase-activating protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF83
    11. XM_054366413.1XP_054222388.1  rho GTPase-activating protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF83
    12. XM_054366419.1XP_054222394.1  rho GTPase-activating protein 21 isoform X8

      UniProtKB/TrEMBL
      B7Z3A3
    13. XM_054366415.1XP_054222390.1  rho GTPase-activating protein 21 isoform X5

      UniProtKB/TrEMBL
      B7Z3A3