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    FEM1B fem-1 homolog B [ Homo sapiens (human) ]

    Gene ID: 10116, updated on 9-Dec-2024

    Summary

    Official Symbol
    FEM1Bprovided by HGNC
    Official Full Name
    fem-1 homolog Bprovided by HGNC
    Primary source
    HGNC:HGNC:3649
    See related
    Ensembl:ENSG00000169018 MIM:613539; AllianceGenome:HGNC:3649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F1AA; F1A-ALPHA; FEM1-beta
    Summary
    This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in brain (RPKM 18.1), endometrium (RPKM 14.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FEM1B in Genome Data Viewer
    Location:
    15q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68277745..68295862)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66096484..66114581)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68570083..68588200)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CLN6 transmembrane ER protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68549209-68549856 Neighboring gene uncharacterized LOC124903593 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:68564472-68565671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68570079-68570980 Neighboring gene NANOG hESC enhancer GRCh37_chr15:68577826-68578327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68607402-68608268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68609715-68610215 Neighboring gene integrin subunit alpha 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68634197-68634792 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:68657127-68658326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68662273-68662774 Neighboring gene Sharpr-MPRA regulatory region 14581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68722903-68723662 Neighboring gene Sharpr-MPRA regulatory region 1870 Neighboring gene uncharacterized LOC124903513

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0396, DKFZp451E0710, DKFZp686G22120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables death receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables death receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein fem-1 homolog B
    Names
    FEM-1-like death receptor binding protein
    fem-1-like death receptor-binding protein alpha
    fem-1-like in apoptotic pathway protein alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015322.5NP_056137.1  protein fem-1 homolog B

      See identical proteins and their annotated locations for NP_056137.1

      Status: REVIEWED

      Source sequence(s)
      AB007856, AC021553, AC107871, BC010122, BF112021
      Consensus CDS
      CCDS10228.1
      UniProtKB/Swiss-Prot
      O43146, Q9UK73
      Related
      ENSP00000307298.4, ENST00000306917.5
      Conserved Domains (3) summary
      PHA03095
      Location:475613
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:158247
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      68277745..68295862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      66096484..66114581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)