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    CCNYL1 cyclin Y like 1 [ Homo sapiens (human) ]

    Gene ID: 151195, updated on 9-Dec-2024

    Summary

    Official Symbol
    CCNYL1provided by HGNC
    Official Full Name
    cyclin Y like 1provided by HGNC
    Primary source
    HGNC:HGNC:26868
    See related
    Ensembl:ENSG00000163249 MIM:620559; AllianceGenome:HGNC:26868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in neurogenesis and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 8.2), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCNYL1 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207711640..207756174)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208185841..208230386)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208576364..208620898)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 2 Neighboring gene RNA, U6 small nuclear 664, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208576168-208577164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208631909-208632465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208632466-208633023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208635695-208636515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17045 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:208636987-208637462 Neighboring gene microRNA 4775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208647704-208648204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208660472-208661457 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208661458-208662442 Neighboring gene frizzled class receptor 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208666419-208666920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208666921-208667420 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208675729-208676550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17048 Neighboring gene pleckstrin homology domain containing M3 Neighboring gene HNF1 motif-containing MPRA enhancer 152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208713897-208714396 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:208772908-208774107 Neighboring gene Sharpr-MPRA regulatory region 2767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:208835249-208835782 Neighboring gene RNA, U6 small nuclear 360, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40432

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142300.2NP_001135772.1  cyclin-Y-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001135772.1

      Status: VALIDATED

      Source sequence(s)
      AA731590, AK026922, AK097751, BC067253, BM772734, CB158848, CN482952, DA730784
      Consensus CDS
      CCDS46503.1
      UniProtKB/Swiss-Prot
      Q8N7R7
      Related
      ENSP00000342344.5, ENST00000339882.9
      Conserved Domains (1) summary
      pfam00134
      Location:119234
      Cyclin_N; Cyclin, N-terminal domain
    2. NM_001330218.2NP_001317147.1  cyclin-Y-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC096772
      Consensus CDS
      CCDS82564.1
      UniProtKB/Swiss-Prot
      Q6NX60, Q8N7R7
      Related
      ENSP00000295414.3, ENST00000295414.8
      Conserved Domains (1) summary
      pfam00134
      Location:163285
      Cyclin_N; Cyclin, N-terminal domain
    3. NM_152523.3NP_689736.1  cyclin-Y-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_689736.1

      Status: VALIDATED

      Source sequence(s)
      AA731590, AK026922, AK095479, AK097751, BM772734, CB158848, DA730784
      Consensus CDS
      CCDS2377.1
      UniProtKB/Swiss-Prot
      Q8N7R7
      Related
      ENSP00000376045.3, ENST00000392209.7
      Conserved Domains (1) summary
      pfam00134
      Location:93215
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      207711640..207756174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      208185841..208230386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)